The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: The COSMIC Collaboration

Perminder S. Sachdev, Darren M. Lipnicki, Nicole A. Kochan, John D. Crawford, Anbupalam Thalamuthu, Gavin Andrews, Carol Brayne, Fiona E. Matthews, Blossom C.M. Stephan, Richard B. Lipton, Mindy J. Katz, Karen Ritchie, Isabelle Carrière, Marie Laure Ancelin, Linda C.W. Lam, Candy H.Y. Wong, Ada W.T. Fung, Antonio Guaita, Roberta Vaccaro, Annalisa DavinMary Ganguli, Hiroko Dodge, Tiffany Hughes, Kaarin J. Anstey, Nicolas Cherbuin, Peter Butterworth, Tze Pin Ng, Qi Gao, Simone Reppermund, Henry Brodaty, Nicole Schupf, Jennifer Manly, Yaakov Stern, Antonio Lobo, Raùl Lopez-Anton, Javier Santabárbara, Molly Zimmerman, Carol Derby, Grace T.Y. Leung, Wai Chi Chan, Letizia Polito, Simona Abbondanza, Eleonora Valle, Mauro Colombo, Silvia Francesca Vitali, Silvia Fossi, Daniele Zaccaria, Gianluigi Forloni, Simona Villani, Helen Christensen, Andrew MacKinnon, Simon Easteal, Trish Jacomb, Karen Maxwell, Allison Bowman, Kim Burns, Anthony Broe, Joula Dekker, Louise Dooley, Michele De Permentier, Sarah Fairjones, Janelle Fletcher, Therese French, Cathy Foster, Emma Nugent-Cleary-Fox, Chien Gooi, Evelyn Harvey, Rebecca Helyer, Sharpley Hsieh, Laura Hughes, Sarah Jacek, Mary Johnston, Donna McCade, Samantha Meeth, Eveline Milne, Angharad Moir, Ros O'Grady, Kia Pfaeffli, Carine Pose, Laura Reuser, Amanda Rose, Peter Schofield, Zeeshan Shahnawaz, Amanda Sharpley, Claire Thompson, Wiebke Queisser, Sam Wong, Richard Mayeux, Adam Brickman, Jose Luchsinger, Danurys Sanchez, Ming X. Tang, Howard Andrews, Guillermo Marcos, Concepción De-La-Cámara, Pedro Saz, Tirso Ventura, Miguel Angel Quintanilla, Elena Lobo

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229 Scopus citations


Background Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI). Methods Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment. Results The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01). Conclusion Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.

Original languageEnglish (US)
Article numbere0142388
JournalPloS one
Issue number11
StatePublished - Nov 5 2015
Externally publishedYes

ASJC Scopus subject areas

  • General


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