The relationship between interleukin-6 and functional connectivity in methamphetamine users

Milky Kohno; Jennifer M. Loftis; Marilyn Huckans; Laura E. Dennis; Holly McCready; William F. Hoffman

doi:10.1016/j.neulet.2018.04.037

The relationship between interleukin-6 and functional connectivity in methamphetamine users

Milky Kohno, Jennifer M. Loftis, Marilyn Huckans, Laura E. Dennis, Holly McCready, William F. Hoffman

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Methamphetamine (MA) causes an increase in pro-inflammatory cytokines in animal models and in humans. Resulting activation of microglia and neuro-inflammation could, via effects on reward networks, mediate behavioral characteristics of addiction. We examined the relationship between interleukin-6 (IL-6) and corticolimbic and striatolimbic resting-state functional connectivity (RSFC). Thirty adults diagnosed with MA dependence and 20 control subjects underwent a resting-state functional magnetic resonance imaging (fMRI) scan and gave a blood sample for determination of plasma IL-6 levels. Seed-based RSFC analyses were performed to examine the interactive effect of group and IL-6 on ventral striatal and prefrontal connectivity. Within the MA group, IL-6 levels were positively related to striatolimbic RSFC but negatively related to corticostriatal RSFC. Our findings with IL-6 support the idea that inflammation may at least partly mediate the link among MA use disorder, RSFC, and behavior, possibly via effects on mesolimbic and mesocortical dopaminergic systems.

Original language	English (US)
Pages (from-to)	49-54
Number of pages	6
Journal	Neuroscience Letters
Volume	677
DOIs	https://doi.org/10.1016/j.neulet.2018.04.037
State	Published - Jun 11 2018

Keywords

Corticostriatal
IL-6
Inflammation
Mesocorticolimbic
Methamphetamine
Resting-state functional connectivity

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2018.04.037

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title = "The relationship between interleukin-6 and functional connectivity in methamphetamine users",

abstract = "Methamphetamine (MA) causes an increase in pro-inflammatory cytokines in animal models and in humans. Resulting activation of microglia and neuro-inflammation could, via effects on reward networks, mediate behavioral characteristics of addiction. We examined the relationship between interleukin-6 (IL-6) and corticolimbic and striatolimbic resting-state functional connectivity (RSFC). Thirty adults diagnosed with MA dependence and 20 control subjects underwent a resting-state functional magnetic resonance imaging (fMRI) scan and gave a blood sample for determination of plasma IL-6 levels. Seed-based RSFC analyses were performed to examine the interactive effect of group and IL-6 on ventral striatal and prefrontal connectivity. Within the MA group, IL-6 levels were positively related to striatolimbic RSFC but negatively related to corticostriatal RSFC. Our findings with IL-6 support the idea that inflammation may at least partly mediate the link among MA use disorder, RSFC, and behavior, possibly via effects on mesolimbic and mesocortical dopaminergic systems.",

keywords = "Corticostriatal, IL-6, Inflammation, Mesocorticolimbic, Methamphetamine, Resting-state functional connectivity",

author = "Milky Kohno and Loftis, {Jennifer M.} and Marilyn Huckans and Dennis, {Laura E.} and Holly McCready and Hoffman, {William F.}",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2018",

month = jun,

day = "11",

doi = "10.1016/j.neulet.2018.04.037",

language = "English (US)",

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T1 - The relationship between interleukin-6 and functional connectivity in methamphetamine users

AU - Kohno, Milky

AU - Loftis, Jennifer M.

AU - Huckans, Marilyn

AU - Dennis, Laura E.

AU - McCready, Holly

AU - Hoffman, William F.

PY - 2018/6/11

Y1 - 2018/6/11

N2 - Methamphetamine (MA) causes an increase in pro-inflammatory cytokines in animal models and in humans. Resulting activation of microglia and neuro-inflammation could, via effects on reward networks, mediate behavioral characteristics of addiction. We examined the relationship between interleukin-6 (IL-6) and corticolimbic and striatolimbic resting-state functional connectivity (RSFC). Thirty adults diagnosed with MA dependence and 20 control subjects underwent a resting-state functional magnetic resonance imaging (fMRI) scan and gave a blood sample for determination of plasma IL-6 levels. Seed-based RSFC analyses were performed to examine the interactive effect of group and IL-6 on ventral striatal and prefrontal connectivity. Within the MA group, IL-6 levels were positively related to striatolimbic RSFC but negatively related to corticostriatal RSFC. Our findings with IL-6 support the idea that inflammation may at least partly mediate the link among MA use disorder, RSFC, and behavior, possibly via effects on mesolimbic and mesocortical dopaminergic systems.

AB - Methamphetamine (MA) causes an increase in pro-inflammatory cytokines in animal models and in humans. Resulting activation of microglia and neuro-inflammation could, via effects on reward networks, mediate behavioral characteristics of addiction. We examined the relationship between interleukin-6 (IL-6) and corticolimbic and striatolimbic resting-state functional connectivity (RSFC). Thirty adults diagnosed with MA dependence and 20 control subjects underwent a resting-state functional magnetic resonance imaging (fMRI) scan and gave a blood sample for determination of plasma IL-6 levels. Seed-based RSFC analyses were performed to examine the interactive effect of group and IL-6 on ventral striatal and prefrontal connectivity. Within the MA group, IL-6 levels were positively related to striatolimbic RSFC but negatively related to corticostriatal RSFC. Our findings with IL-6 support the idea that inflammation may at least partly mediate the link among MA use disorder, RSFC, and behavior, possibly via effects on mesolimbic and mesocortical dopaminergic systems.

KW - Corticostriatal

KW - IL-6

KW - Inflammation

KW - Mesocorticolimbic

KW - Methamphetamine

KW - Resting-state functional connectivity

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The relationship between interleukin-6 and functional connectivity in methamphetamine users

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Keywords

ASJC Scopus subject areas

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