The role of CuCu dinuclear complexes in the oxidation of ascorbic acid by O2 a model for copper-oxidase activity

R. F. Jameson; N. J. Blackburn

doi:10.1016/0022-1902(75)80544-6

The role of CuCu dinuclear complexes in the oxidation of ascorbic acid by O₂ a model for copper-oxidase activity

R. F. Jameson, N. J. Blackburn

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Abstract

The copper(II) catalysed oxidation of ascorbate by molecular oxygen has been re-investigated. The kinetics require that electron transfer from a dinuclear copper-ascorbate complex to dioxygen be invoked as the initial step in the mechanism in nitrate, fluoride and chloride media, the reaction thus being presumed to go through a higher, rather than a lower, oxidation state intermediate. The catalytic mechanism of copper-oxidases is discussed in terms of this 'model' system, the former also containing CuCu dinuclear units as oxygen binding sites.

Original language	English (US)
Pages (from-to)	809-814
Number of pages	6
Journal	Journal of Inorganic and Nuclear Chemistry
Volume	37
Issue number	3
DOIs	https://doi.org/10.1016/0022-1902(75)80544-6
State	Published - Mar 1975
Externally published	Yes

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abstract = "The copper(II) catalysed oxidation of ascorbate by molecular oxygen has been re-investigated. The kinetics require that electron transfer from a dinuclear copper-ascorbate complex to dioxygen be invoked as the initial step in the mechanism in nitrate, fluoride and chloride media, the reaction thus being presumed to go through a higher, rather than a lower, oxidation state intermediate. The catalytic mechanism of copper-oxidases is discussed in terms of this 'model' system, the former also containing CuCu dinuclear units as oxygen binding sites.",

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year = "1975",

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AU - Jameson, R. F.

AU - Blackburn, N. J.

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Y1 - 1975/3

N2 - The copper(II) catalysed oxidation of ascorbate by molecular oxygen has been re-investigated. The kinetics require that electron transfer from a dinuclear copper-ascorbate complex to dioxygen be invoked as the initial step in the mechanism in nitrate, fluoride and chloride media, the reaction thus being presumed to go through a higher, rather than a lower, oxidation state intermediate. The catalytic mechanism of copper-oxidases is discussed in terms of this 'model' system, the former also containing CuCu dinuclear units as oxygen binding sites.

AB - The copper(II) catalysed oxidation of ascorbate by molecular oxygen has been re-investigated. The kinetics require that electron transfer from a dinuclear copper-ascorbate complex to dioxygen be invoked as the initial step in the mechanism in nitrate, fluoride and chloride media, the reaction thus being presumed to go through a higher, rather than a lower, oxidation state intermediate. The catalytic mechanism of copper-oxidases is discussed in terms of this 'model' system, the former also containing CuCu dinuclear units as oxygen binding sites.

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The role of CuCu dinuclear complexes in the oxidation of ascorbic acid by O₂ a model for copper-oxidase activity

Abstract

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