Abstract
The male rabbit liver microsomal cytochrome P450 metabolism of 1‐nitropyrene and 3‐nitrofluoranthene was investigated. In this study, we used inhibitory antibodies specific for rabbit P450 2C3 and determined that, in untreated male rabbit liver microsomes, the antibody inhibited approximately 75% of the cytochrome P450‐mediated C‐oxidation of both 1‐nitropyrene and 3‐nitrofluoranthene. These results verify our previous prediction that mainly one cytochrome P450 is responsible for microsomal metabolism of 1‐nitropyrene in the untreated rabbit liver.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 71-78 |
| Number of pages | 8 |
| Journal | Journal of Biochemical Toxicology |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1994 |
Keywords
- 1‐Nitropyrene
- 3‐Nitrofluoranthene
- Cytochrome P450
- Environmental Carcinogen
- Microsomal Metabolism
ASJC Scopus subject areas
- Toxicology