The role of insulin-like growth factors in prostate biology

Donna M. Peehl, Pinchas Cohen, Ron G. Rosenfeld

Research output: Contribution to journalShort surveypeer-review

53 Scopus citations


Characterization of the IGF system in cultured prostatic epithelial and stromal cells has established a model for the biological role of IGFs in the prostate. The specific components of the IGF system differ between the stroma and the epithelium, and they may differ among normal, BPH, and malignant tissues. Abnormalities in the IGF system that have been observed in stromal cells derived from BPH may provide a basis for the etiology of BPH and for new therapeutic strategies. Several abnormalities in the IGF system, including increased IGFBP-2 and decreased IGFBP-3 in sera, may be associated with prostate cancer. Furthermore, PSA may cause increased mitogenic activity of IGF by cleavage of IGFBP-3 in local areas surrounding prostate cancer at either primary or metastic sites. Future studies will aim to validate these models in vivo by in situ hybridization, immunohistochemistry, and other techniques.

Original languageEnglish (US)
Pages (from-to)2-4
Number of pages3
JournalJournal of Andrology
Issue number1
StatePublished - Jan 1996
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Urology


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