Abstract
The development of EGFR inhibitors has influenced the field of targeted therapeutics significantly. Unfortunately, the benefits of EGFR inhibitors are limited by several mechanisms of drug resistance, which include KRAS mutations. Mutations in this gene result in constitutive activation of the Ras/Raf/MEK/ERK pathway, with loss of EGFR signaling control, rendering inhibitors of EGFR ineffective. Several strategies are being developed to overcome this mechanism of resistance, including MEK inhibitors, Braf inhibitors, Hsp90 inhibitors, K-Ras-directed immunotherapy, mTOR inhibitors and several combination approaches.
Original language | English (US) |
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Pages (from-to) | 1305-1314 |
Number of pages | 10 |
Journal | Current Opinion in Investigational Drugs |
Volume | 10 |
Issue number | 12 |
State | Published - Dec 2009 |
Externally published | Yes |
Keywords
- Colorectal cancer
- EGFR
- Erb-B1
- K-Ras
- KRAS
- Lung cancer
- Pancreatic cancer
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery