The role of NMDA receptor binding sites in ethanol place conditioning

Janel M. Boyce-Rustay, Christopher L. Cunningham

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Little is known about the specific role of glutamate, in particular its actions at N-methyl-D-aspartate (NMDA) receptors, in ethanol reward. Pretreatment with channel blockers MK-801 and ketamine, NMDA NR2B receptor subunit antagonists ifenprodil and CP-101,606, and the glycineB partial agonist (+)-HA-966 did not alter acquisition of ethanol-induced conditioned place preference (CPP) in mice. However, pretreatment with the competitive antagonist CGP-37849 attenuated acquisition of ethanol-induced CPP. Follow-up experiments indicated that CGP-37849 also blocked acquisition of ethanol-induced and lithium chloride-induced conditioned place aversion but did not produce rewarding or aversive effects on its own. These results suggest that the NMDA receptor glutamate binding site is important for ethanol place conditioning. Moreover, these results suggest CGP-37849 modulates ethanol place conditioning by impairing the ability to learn these tasks.

Original languageEnglish (US)
Pages (from-to)822-834
Number of pages13
JournalBehavioral Neuroscience
Issue number4
StatePublished - Aug 2004
Externally publishedYes

ASJC Scopus subject areas

  • Behavioral Neuroscience


Dive into the research topics of 'The role of NMDA receptor binding sites in ethanol place conditioning'. Together they form a unique fingerprint.

Cite this