The role of T cells in autoimmune uveitis

M. D. Becker; G. Adamus; M. P. Davey; J. T. Rosenbaum

doi:10.1076/0927-3948(200006)821-0ft093

The role of T cells in autoimmune uveitis

M. D. Becker, G. Adamus, M. P. Davey, J. T. Rosenbaum

Research output: Contribution to journal › Short survey › peer-review

37 Scopus citations

Abstract

Autoimmune diseases result from the activation of self-reactive T cells recognizing autoantigens or foreign antigens cross-reactive with an autoantigen. T cells are thought to play a major role in autoimmune diseases in different organs, including the eye. This review focuses on the role of T cells in autoimmune uveitis in humans and in animal models of experimental autoimmune uveitis. Since rheumatoid arthritis is an autoimmune disease that has been studied far more extensively than uveitis, we have also included a review of clinical and experimental observations relevant to that disease.

Original language	English (US)
Pages (from-to)	93-100
Number of pages	8
Journal	Ocular Immunology and Inflammation
Volume	8
Issue number	2
DOIs	https://doi.org/10.1076/0927-3948(200006)821-0ft093
State	Published - 2000

Keywords

Autoimmunity
Experimental uveitis
Pathomechanisms
T lymphocytes

ASJC Scopus subject areas

Immunology and Allergy
Ophthalmology

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10.1076/0927-3948(200006)821-0ft093

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title = "The role of T cells in autoimmune uveitis",

abstract = "Autoimmune diseases result from the activation of self-reactive T cells recognizing autoantigens or foreign antigens cross-reactive with an autoantigen. T cells are thought to play a major role in autoimmune diseases in different organs, including the eye. This review focuses on the role of T cells in autoimmune uveitis in humans and in animal models of experimental autoimmune uveitis. Since rheumatoid arthritis is an autoimmune disease that has been studied far more extensively than uveitis, we have also included a review of clinical and experimental observations relevant to that disease.",

keywords = "Autoimmunity, Experimental uveitis, Pathomechanisms, T lymphocytes",

author = "Becker, {M. D.} and G. Adamus and Davey, {M. P.} and Rosenbaum, {J. T.}",

note = "Funding Information: Research grant from Deutsche Forschungsgemeinschaft, Germany Be 1795/3-1; NIH grants EY13093, EY06484, EY06477, EY12477 (GA); Research to Prevent Blindness Awards to JTR and the Casey Eye Institute; Merit Review research grant from the Department of Veterans Affairs (MPD).",

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doi = "10.1076/0927-3948(200006)821-0ft093",

language = "English (US)",

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T1 - The role of T cells in autoimmune uveitis

AU - Becker, M. D.

AU - Adamus, G.

AU - Davey, M. P.

AU - Rosenbaum, J. T.

N1 - Funding Information: Research grant from Deutsche Forschungsgemeinschaft, Germany Be 1795/3-1; NIH grants EY13093, EY06484, EY06477, EY12477 (GA); Research to Prevent Blindness Awards to JTR and the Casey Eye Institute; Merit Review research grant from the Department of Veterans Affairs (MPD).

PY - 2000

Y1 - 2000

N2 - Autoimmune diseases result from the activation of self-reactive T cells recognizing autoantigens or foreign antigens cross-reactive with an autoantigen. T cells are thought to play a major role in autoimmune diseases in different organs, including the eye. This review focuses on the role of T cells in autoimmune uveitis in humans and in animal models of experimental autoimmune uveitis. Since rheumatoid arthritis is an autoimmune disease that has been studied far more extensively than uveitis, we have also included a review of clinical and experimental observations relevant to that disease.

AB - Autoimmune diseases result from the activation of self-reactive T cells recognizing autoantigens or foreign antigens cross-reactive with an autoantigen. T cells are thought to play a major role in autoimmune diseases in different organs, including the eye. This review focuses on the role of T cells in autoimmune uveitis in humans and in animal models of experimental autoimmune uveitis. Since rheumatoid arthritis is an autoimmune disease that has been studied far more extensively than uveitis, we have also included a review of clinical and experimental observations relevant to that disease.

KW - Autoimmunity

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KW - Pathomechanisms

KW - T lymphocytes

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The role of T cells in autoimmune uveitis

Abstract

Keywords

ASJC Scopus subject areas

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