The role of the spleen in ischemic stroke

Keith R. Pennypacker; Halina Offner

doi:10.1038/jcbfm.2014.212

The role of the spleen in ischemic stroke

Keith R. Pennypacker, Halina Offner

Neurology

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

This opinion piece highlights the scientific literature reporting that the peripheral immune response to ischemic stroke originates from the spleen. Removal of the spleen not only reduces stroke-induced neurodegeneration but also cellular degeneration in the body's other tissues when exposed to ischemic conditions.

Original language	English (US)
Pages (from-to)	186-187
Number of pages	2
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	35
Issue number	2
DOIs	https://doi.org/10.1038/jcbfm.2014.212
State	Published - Feb 2 2015

Keywords

brain ischemia
macrophages
neuroinflammation

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1038/jcbfm.2014.212

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title = "The role of the spleen in ischemic stroke",

abstract = "This opinion piece highlights the scientific literature reporting that the peripheral immune response to ischemic stroke originates from the spleen. Removal of the spleen not only reduces stroke-induced neurodegeneration but also cellular degeneration in the body's other tissues when exposed to ischemic conditions.",

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KW - neuroinflammation

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The role of the spleen in ischemic stroke

Abstract

Keywords

ASJC Scopus subject areas

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