The second filter's second coming

Sripriya Ramamoorthy, Fangyi Chen, Dingjun Zha, Steven Jacques, Ruikang Wang, Niloy Choudhoury, Alfred L. Nuttall, Anders Fridberger

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We measured sound-evoked vibrations at the stereociliary side of inner and outer hair cells and their surrounding supporting cells, using optical coherence tomography interferometry in living anesthetized Guinea pigs. Our measurements demonstrate a gradient in frequency tuning among different cell types, going from a high best frequency at the inner hair cells to a lower one at the Hensen cells. This causes the locus of maximum inner hair cell activation to be shifted toward the apex of the cochlea as compared to the outer hair cells. These observations show that additional processing and filtering of acoustic signals occurs within the organ of Corti prior to inner hair cell excitation, thus reinstating a transformed second filter as a mechanism contributing to cochlear frequency tuning.

Original languageEnglish (US)
Title of host publicationMechanics of Hearing: Protein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735413504
StatePublished - Dec 31 2015
Event12th International Workshop on the Mechanics of Hearing: Protein to Perception - Cape Sounio, Greece
Duration: Jun 23 2014Jun 29 2014


Other12th International Workshop on the Mechanics of Hearing: Protein to Perception
CityCape Sounio

ASJC Scopus subject areas

  • Physics and Astronomy(all)


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