The sheep as a model of brain injury in the premature infant

Stephen A. Back, Art Riddle, A. Roger Hohimer

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Preterm fetal sheep preparations provide unique experimental access to the complex pathophysiological processes that contribute to injury to the human brain during successive periods in development. Recent refinements have resulted in preparations that offer a number of significant advantages to model key aspects of human preterm cerebral injury. We describe a global cerebral ischemia preparation that replicates major features of acute and chronic human cerebral injury and which has provided access to complex clinically relevant studies of cerebral blood flow and neuro-imaging that are not feasible in smaller laboratory animals. Despite the higher costs and technical challenges of instrumented preterm fetal sheep models, they allow an integrated analysis of the spectrum of insults that appear to contribute to cerebral injury in human preterm infants.

Original languageEnglish (US)
Title of host publicationNeuromethods
PublisherHumana Press Inc.
Number of pages22
StatePublished - Sep 22 2015

Publication series

ISSN (Print)0893-2336
ISSN (Electronic)1940-6045


  • Apoptosis
  • Cerebral blood flow
  • Hypoxia-ischemia
  • MRI
  • Necrosis
  • Oligodendrocyte
  • White matter injury

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology
  • General Neuroscience


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