The trim5α genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge

Matthew R. Reynolds; Jonah B. Sacha; Andrea M. Weiler; Gretta J. Borchardt; Chrystal E. Glidden; Neil C. Sheppard; Francesca A. Norante; Philip A. Castrovinci; Jacqueline J. Harris; Henry T. Robertson; Thomas C. Friedrich; Adrian B. McDermott; Nancy A. Wilson; David B. Allison; Wayne C. Koff; Welkin E. Johnson; David I. Watkins

doi:10.1128/JVI.05074-11

The trim5α genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge

Matthew R. Reynolds, Jonah B. Sacha, Andrea M. Weiler, Gretta J. Borchardt, Chrystal E. Glidden, Neil C. Sheppard, Francesca A. Norante, Philip A. Castrovinci, Jacqueline J. Harris, Henry T. Robertson, Thomas C. Friedrich, Adrian B. McDermott, Nancy A. Wilson, David B. Allison, Wayne C. Koff, Welkin E. Johnson, David I. Watkins

Oregon National Primate Research Center

Research output: Contribution to journal › Comment/debate › peer-review

57 Scopus citations

Abstract

It has recently been shown that polymorphism at the rhesus macaque TRIM5 locus can affect simian immunodeficiency virus (SIV) replication. Here we show that TRIM5 alleles can also affect acquisition of SIVsmE660. Animals coexpressing the TRIM5 ^TFP and TRIM5 ^CypA alleles took significantly longer to become infected with SIVsmE660, but not SIVmac239, after repeated limiting-dose intrarectal challenge than did animals expressing other TRIM5 allele combinations. Our results indicate that the TRIM5 alleles can be a barrier to productive infection and that this should be taken into account when designing acquisition studies using SIVsmE660 or related viruses.

Original language	English (US)
Pages (from-to)	9637-9640
Number of pages	4
Journal	Journal of virology
Volume	85
Issue number	18
DOIs	https://doi.org/10.1128/JVI.05074-11
State	Published - Sep 2011

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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Reynolds, M. R., Sacha, J. B., Weiler, A. M., Borchardt, G. J., Glidden, C. E., Sheppard, N. C., Norante, F. A., Castrovinci, P. A., Harris, J. J., Robertson, H. T., Friedrich, T. C., McDermott, A. B., Wilson, N. A., Allison, D. B., Koff, W. C., Johnson, W. E., & Watkins, D. I. (2011). The trim5α genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge. Journal of virology, 85(18), 9637-9640. https://doi.org/10.1128/JVI.05074-11

The trim5α genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge. / Reynolds, Matthew R.; Sacha, Jonah B.; Weiler, Andrea M. et al.
In: Journal of virology, Vol. 85, No. 18, 09.2011, p. 9637-9640.

Research output: Contribution to journal › Comment/debate › peer-review

Reynolds, MR, Sacha, JB, Weiler, AM, Borchardt, GJ, Glidden, CE, Sheppard, NC, Norante, FA, Castrovinci, PA, Harris, JJ, Robertson, HT, Friedrich, TC, McDermott, AB, Wilson, NA, Allison, DB, Koff, WC, Johnson, WE & Watkins, DI 2011, 'The trim5α genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge', Journal of virology, vol. 85, no. 18, pp. 9637-9640. https://doi.org/10.1128/JVI.05074-11

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title = "The trim5α genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge",

abstract = "It has recently been shown that polymorphism at the rhesus macaque TRIM5 locus can affect simian immunodeficiency virus (SIV) replication. Here we show that TRIM5 alleles can also affect acquisition of SIVsmE660. Animals coexpressing the TRIM5 TFP and TRIM5 CypA alleles took significantly longer to become infected with SIVsmE660, but not SIVmac239, after repeated limiting-dose intrarectal challenge than did animals expressing other TRIM5 allele combinations. Our results indicate that the TRIM5 alleles can be a barrier to productive infection and that this should be taken into account when designing acquisition studies using SIVsmE660 or related viruses.",

author = "Reynolds, {Matthew R.} and Sacha, {Jonah B.} and Weiler, {Andrea M.} and Borchardt, {Gretta J.} and Glidden, {Chrystal E.} and Sheppard, {Neil C.} and Norante, {Francesca A.} and Castrovinci, {Philip A.} and Harris, {Jacqueline J.} and Robertson, {Henry T.} and Friedrich, {Thomas C.} and McDermott, {Adrian B.} and Wilson, {Nancy A.} and Allison, {David B.} and Koff, {Wayne C.} and Johnson, {Welkin E.} and Watkins, {David I.}",

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AU - Borchardt, Gretta J.

AU - Glidden, Chrystal E.

AU - Sheppard, Neil C.

AU - Norante, Francesca A.

AU - Castrovinci, Philip A.

AU - Harris, Jacqueline J.

AU - Robertson, Henry T.

AU - Friedrich, Thomas C.

AU - McDermott, Adrian B.

AU - Wilson, Nancy A.

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AB - It has recently been shown that polymorphism at the rhesus macaque TRIM5 locus can affect simian immunodeficiency virus (SIV) replication. Here we show that TRIM5 alleles can also affect acquisition of SIVsmE660. Animals coexpressing the TRIM5 TFP and TRIM5 CypA alleles took significantly longer to become infected with SIVsmE660, but not SIVmac239, after repeated limiting-dose intrarectal challenge than did animals expressing other TRIM5 allele combinations. Our results indicate that the TRIM5 alleles can be a barrier to productive infection and that this should be taken into account when designing acquisition studies using SIVsmE660 or related viruses.

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The trim5α genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge

Abstract

ASJC Scopus subject areas

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