The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study

Jane M. Simoni; David Huh; Yan Wang; Ira B. Wilson; Nancy R. Reynolds; Robert H. Remien; Kathy Goggin; Robert Gross; Marc I. Rosen; Neil Schneiderman; Julia Arnsten; Carol E. Golin; Judith A. Erlen; David R. Bangsberg; Honghu Liu

doi:10.1007/s10461-014-0905-x

The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study

Jane M. Simoni, David Huh, Yan Wang, Ira B. Wilson, Nancy R. Reynolds, Robert H. Remien, Kathy Goggin, Robert Gross, Marc I. Rosen, Neil Schneiderman, Julia Arnsten, Carol E. Golin, Judith A. Erlen, David R. Bangsberg, Honghu Liu

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

In medication adherence-promotion trials, participants in the intervention arm are often cognizant of the researcher’s aim to improve adherence; this may lead to their inflating reports of their own adherence compared to control arm participants. Using data from 1,247 HIV-positive participants across eight U.S. Studies in the Multi-site Adherence Collaboration on HIV (MACH14) collaboration, we evaluated the validity of self-reported adherence by examining whether its association with two more objective outcomes [1], electronically monitored adherence and [2] viral load, varied by study arm. After adjusting for potential confounders, there was no evidence of greater overestimation of self-reported adherence among intervention arm participants, supporting its potential as a trial outcome indicator.

Original language	English (US)
Pages (from-to)	2285-2290
Number of pages	6
Journal	AIDS and Behavior
Volume	18
Issue number	12
DOIs	https://doi.org/10.1007/s10461-014-0905-x
State	Published - Dec 1 2014
Externally published	Yes

Keywords

HIV/AIDS
Intervention studies
Medication adherence assessment
Social desirability

ASJC Scopus subject areas

Social Psychology
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1007/s10461-014-0905-x

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Simoni, J. M., Huh, D., Wang, Y., Wilson, I. B., Reynolds, N. R., Remien, R. H., Goggin, K., Gross, R., Rosen, M. I., Schneiderman, N., Arnsten, J., Golin, C. E., Erlen, J. A., Bangsberg, D. R., & Liu, H. (2014). The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study. AIDS and Behavior, 18(12), 2285-2290. https://doi.org/10.1007/s10461-014-0905-x

Simoni, JM, Huh, D, Wang, Y, Wilson, IB, Reynolds, NR, Remien, RH, Goggin, K, Gross, R, Rosen, MI, Schneiderman, N, Arnsten, J, Golin, CE, Erlen, JA, Bangsberg, DR & Liu, H 2014, 'The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study', AIDS and Behavior, vol. 18, no. 12, pp. 2285-2290. https://doi.org/10.1007/s10461-014-0905-x

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abstract = "In medication adherence-promotion trials, participants in the intervention arm are often cognizant of the researcher{\textquoteright}s aim to improve adherence; this may lead to their inflating reports of their own adherence compared to control arm participants. Using data from 1,247 HIV-positive participants across eight U.S. Studies in the Multi-site Adherence Collaboration on HIV (MACH14) collaboration, we evaluated the validity of self-reported adherence by examining whether its association with two more objective outcomes [1], electronically monitored adherence and [2] viral load, varied by study arm. After adjusting for potential confounders, there was no evidence of greater overestimation of self-reported adherence among intervention arm participants, supporting its potential as a trial outcome indicator.",

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author = "Simoni, {Jane M.} and David Huh and Yan Wang and Wilson, {Ira B.} and Reynolds, {Nancy R.} and Remien, {Robert H.} and Kathy Goggin and Robert Gross and Rosen, {Marc I.} and Neil Schneiderman and Julia Arnsten and Golin, {Carol E.} and Erlen, {Judith A.} and Bangsberg, {David R.} and Honghu Liu",

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The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study

Abstract

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