TY - JOUR
T1 - The varied spectrum of nephroblastomatosis, nephrogenic rests, and Wilms tumors
T2 - Review of current definitions and challenges of the field
AU - Fialkowski, Elizabeth
AU - Sudour-Bonnange, Hélène
AU - Vujanic, Gordan M.
AU - Shamberger, Robert C.
AU - Chowdhury, Tanzina
AU - Aldrink, Jennifer H.
AU - Davick, Jonathan
AU - Sandberg, Jesse
AU - Furtwaengler, Rhoikos
AU - Mullen, Elizabeth
N1 - Publisher Copyright:
© 2022 Wiley Periodicals LLC.
PY - 2023/5
Y1 - 2023/5
N2 - The diagnosis of multiple or diffuse renal lesions in a child is challenging by imaging and/or pathology. Optimal management requires distinguishing benign lesions such as nephrogenic rests from cancerous lesions such as Wilms tumor, but this is often difficult or impossible. This difficulty is compounded by the overlapping nature of our current radiologic and pathologic definitions of lesions along the spectrum of nephrogenic rests/nephroblastomatosis. We provide a review of these issues, as a collaborative effort between the Children's Oncology Group Renal Tumor Committee and International Society of Pediatric Oncology Renal Tumor Study Group. Our aim is to discuss current challenges in diagnosis and management of these renal lesions, encouraging future work toward consensus definitions for research and patient care.
AB - The diagnosis of multiple or diffuse renal lesions in a child is challenging by imaging and/or pathology. Optimal management requires distinguishing benign lesions such as nephrogenic rests from cancerous lesions such as Wilms tumor, but this is often difficult or impossible. This difficulty is compounded by the overlapping nature of our current radiologic and pathologic definitions of lesions along the spectrum of nephrogenic rests/nephroblastomatosis. We provide a review of these issues, as a collaborative effort between the Children's Oncology Group Renal Tumor Committee and International Society of Pediatric Oncology Renal Tumor Study Group. Our aim is to discuss current challenges in diagnosis and management of these renal lesions, encouraging future work toward consensus definitions for research and patient care.
KW - Wilms tumors
KW - nephroblastomatosis
KW - nephrogenic rests
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U2 - 10.1002/pbc.30162
DO - 10.1002/pbc.30162
M3 - Article
C2 - 36545945
AN - SCOPUS:85144885174
SN - 1545-5009
VL - 70
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - S2
M1 - e30162
ER -