The viral infectivity factor (Vif) of HIV-1 unveiled

Kristine M. Rose; Mariana Marin; Susan L. Kozak; David Kabat

doi:10.1016/j.molmed.2004.04.008

The viral infectivity factor (Vif) of HIV-1 unveiled

Kristine M. Rose
, Mariana Marin
, Susan L. Kozak
, David Kabat

Biochemistry & Molecular Biology

Research output: Contribution to journal › Review article › peer-review

51 Scopus citations

Abstract

The viral infectivity factor (Vif) of HIV type-1 (HIV-1) is essential for efficient viral replication, yet was, until recently, enigmatic. This resulted from the complexity and cellular specificity of its function and the correspondingly complex systems that are required for its investigation. These limitations have been overcome and Vif function has been rapidly elucidated, with implications for the development of drugs to block its activity. These studies have revealed a novel component of the innate immune system, APOBEC3G, that lethally hypermutates retroviruses, including HIV-1. For HIV-1, the competition between the virus and APOBEC3G is tipped in favor of the invader by Vif, which binds to APOBEC3G and triggers its polyubiquitination and rapid degradation, thereby preventing its entry into progeny virions.

Original language	English (US)
Pages (from-to)	291-297
Number of pages	7
Journal	Trends in Molecular Medicine
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/j.molmed.2004.04.008
State	Published - Jun 1 2004

Funding

Our work on Vif and in preparation of this manuscript were supported by NIH grant AI49729 from the US Public Health Service.

Funders	Funder number
US Public Health Service
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health
National Institute of Allergy and Infectious Diseases	R01AI049729

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

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10.1016/j.molmed.2004.04.008

Cite this

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title = "The viral infectivity factor (Vif) of HIV-1 unveiled",

abstract = "The viral infectivity factor (Vif) of HIV type-1 (HIV-1) is essential for efficient viral replication, yet was, until recently, enigmatic. This resulted from the complexity and cellular specificity of its function and the correspondingly complex systems that are required for its investigation. These limitations have been overcome and Vif function has been rapidly elucidated, with implications for the development of drugs to block its activity. These studies have revealed a novel component of the innate immune system, APOBEC3G, that lethally hypermutates retroviruses, including HIV-1. For HIV-1, the competition between the virus and APOBEC3G is tipped in favor of the invader by Vif, which binds to APOBEC3G and triggers its polyubiquitination and rapid degradation, thereby preventing its entry into progeny virions.",

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note = "Funding Information: Our work on Vif and in preparation of this manuscript were supported by NIH grant AI49729 from the US Public Health Service.",

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AU - Marin, Mariana

AU - Kozak, Susan L.

AU - Kabat, David

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The viral infectivity factor (Vif) of HIV-1 unveiled

Abstract

Funding

ASJC Scopus subject areas

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