Thermally sensitive fluorescence imaging system for radiofrequency ablation guidance

Xiaoxia Guo; Yongkang Gai; Fang Du; Qingbing Wang; Lingyi Sun; Xiaoyi Ding; Dexing Zeng; Zhiyuan Wu

doi:10.1080/02656736.2020.1742934

Thermally sensitive fluorescence imaging system for radiofrequency ablation guidance

Xiaoxia Guo, Yongkang Gai, Fang Du, Qingbing Wang, Lingyi Sun, Xiaoyi Ding, Dexing Zeng, Zhiyuan Wu

Diagnostic Radiology

Research output: Contribution to journal › Article › peer-review

Abstract

Radiofrequency ablation (RFA) has been clinically used as a minimally invasive procedure for the treatment of many solid tumors. However, the current imaging techniques have some shortages in RFA guidance, especially for the assessment of the margin of ablation. Herein, we developed a novel optical imaging platform to guide RFA utilizing fluorescence resonance energy transfer from a thermally sensitive fluorescent protein conjugated to a near-infrared fluorescent dye. Additionally, attaching receptor-targeting ligands further equipped the system with high specificity to tumors overexpressing the targeted receptor.

Original language	English (US)
Pages (from-to)	308-315
Number of pages	8
Journal	International Journal of Hyperthermia
Volume	37
Issue number	1
DOIs	https://doi.org/10.1080/02656736.2020.1742934
State	Published - Jan 1 2020

Keywords

Fluorescence imaging
cancer
fluorescence resonance energy transfer
radiofrequency ablation
thermally sensitive

ASJC Scopus subject areas

Physiology
Physiology (medical)
Cancer Research

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10.1080/02656736.2020.1742934

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title = "Thermally sensitive fluorescence imaging system for radiofrequency ablation guidance",

abstract = "Radiofrequency ablation (RFA) has been clinically used as a minimally invasive procedure for the treatment of many solid tumors. However, the current imaging techniques have some shortages in RFA guidance, especially for the assessment of the margin of ablation. Herein, we developed a novel optical imaging platform to guide RFA utilizing fluorescence resonance energy transfer from a thermally sensitive fluorescent protein conjugated to a near-infrared fluorescent dye. Additionally, attaching receptor-targeting ligands further equipped the system with high specificity to tumors overexpressing the targeted receptor.",

keywords = "Fluorescence imaging, cancer, fluorescence resonance energy transfer, radiofrequency ablation, thermally sensitive",

author = "Xiaoxia Guo and Yongkang Gai and Fang Du and Qingbing Wang and Lingyi Sun and Xiaoyi Ding and Dexing Zeng and Zhiyuan Wu",

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AU - Guo, Xiaoxia

AU - Gai, Yongkang

AU - Du, Fang

AU - Wang, Qingbing

AU - Sun, Lingyi

AU - Ding, Xiaoyi

AU - Zeng, Dexing

AU - Wu, Zhiyuan

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Radiofrequency ablation (RFA) has been clinically used as a minimally invasive procedure for the treatment of many solid tumors. However, the current imaging techniques have some shortages in RFA guidance, especially for the assessment of the margin of ablation. Herein, we developed a novel optical imaging platform to guide RFA utilizing fluorescence resonance energy transfer from a thermally sensitive fluorescent protein conjugated to a near-infrared fluorescent dye. Additionally, attaching receptor-targeting ligands further equipped the system with high specificity to tumors overexpressing the targeted receptor.

AB - Radiofrequency ablation (RFA) has been clinically used as a minimally invasive procedure for the treatment of many solid tumors. However, the current imaging techniques have some shortages in RFA guidance, especially for the assessment of the margin of ablation. Herein, we developed a novel optical imaging platform to guide RFA utilizing fluorescence resonance energy transfer from a thermally sensitive fluorescent protein conjugated to a near-infrared fluorescent dye. Additionally, attaching receptor-targeting ligands further equipped the system with high specificity to tumors overexpressing the targeted receptor.

KW - Fluorescence imaging

KW - cancer

KW - fluorescence resonance energy transfer

KW - radiofrequency ablation

KW - thermally sensitive

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Thermally sensitive fluorescence imaging system for radiofrequency ablation guidance

Abstract

Keywords

ASJC Scopus subject areas

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