Thymoma: State of the art

Charles R. Thomas, Cameron D. Wright, Patrick J. Loehrer

Research output: Contribution to journalReview articlepeer-review

265 Scopus citations


Thymoma is the most common tumor of the anterior mediastinum. This tumor is associated with unique paraneoplastic syndromes, such as myasthenia gravis, hypogammaglobulinemia, and pure red cell aplasia. The rarity of this tumor, however, has somewhat obscured the optimal treatment for this disease. For the majority of patients who present with localized tumor, surgical extirpation remains the standard of choice. Adjuvant radiotherapy seems to improve local control and survival. In more advanced disease, systemic therapy has been demonstrated to produce a 50% to 80% objective response rate. These observations have led to the development of multimodality therapy for the treatment of patients with advanced thymoma. In this article, we will review the current perspectives on the management of early stage and advanced thymoma.

Original languageEnglish (US)
Pages (from-to)2280-2289
Number of pages10
JournalJournal of Clinical Oncology
Issue number7
StatePublished - Jul 1999

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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