Thyrotropin-releasing hormone (TRH) content of rat striatum: Modification by drugs and lesions

Eliot R. Spindel; Douglas J. Pettibone; Richard J. Wurtman

doi:10.1016/0006-8993(81)90134-7

Thyrotropin-releasing hormone (TRH) content of rat striatum: Modification by drugs and lesions

Eliot R. Spindel
, Douglas J. Pettibone
, Richard J. Wurtman

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Two hours after injection, d-amphetamine sulfate (10 mg/kg, i.p.) lowered thyrotropin-releasing hormone (TRH) levels in rat striatum by 50%, but produced no significant changes in the TRH contents of hypothalamus, septum, brain stem or preoptic area. The effect peaked 2 h after amphetamine injection and declined slowly thereafter. The amphetamine-induced decrease in striatal TRH could be blocked by pretreatment with haloperidol or α-methyltyrosine, or by production of a 6-hydroxydopamine lesion in the ipsilateral substantia nigra. Amphetamine did not act by inhibiting protein synthesis in as much as cycloheximide did not similarly decrease striatal TRH. Kainic acid injected into the striatum lowered TRH by 30% after 5 days. In contrast, partial deafferentation of the striatum (by cerebral hemitransection at mid-hypothalamic level) increased striatal TRH 2-3-fold, while lesions of the dorsal raphe did not significantly change striatal TRH. Thus TRH levels in rat striatum are closely regulated by dopaminergic and other neurotransmitter systems.

Original language	English (US)
Pages (from-to)	323-331
Number of pages	9
Journal	Brain Research
Volume	216
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(81)90134-7
State	Published - Jul 20 1981
Externally published	Yes

Funding

These studies were supported by grants from the International Life Sciences Institute and the National Institutes of Health. We thank Dr. Franz Hefti for advice on stereotaxic procedures, Dr. Arthur Schlossberg for performing the raphe lesions and Dr. Alan Sved for the serotonin analysis.

Funders
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health
International Life Sciences Institute

Keywords

amphetamine
dopamine
striatum
thyrotropin-releasing hormone

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(81)90134-7

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title = "Thyrotropin-releasing hormone (TRH) content of rat striatum: Modification by drugs and lesions",

abstract = "Two hours after injection, d-amphetamine sulfate (10 mg/kg, i.p.) lowered thyrotropin-releasing hormone (TRH) levels in rat striatum by 50\%, but produced no significant changes in the TRH contents of hypothalamus, septum, brain stem or preoptic area. The effect peaked 2 h after amphetamine injection and declined slowly thereafter. The amphetamine-induced decrease in striatal TRH could be blocked by pretreatment with haloperidol or α-methyltyrosine, or by production of a 6-hydroxydopamine lesion in the ipsilateral substantia nigra. Amphetamine did not act by inhibiting protein synthesis in as much as cycloheximide did not similarly decrease striatal TRH. Kainic acid injected into the striatum lowered TRH by 30\% after 5 days. In contrast, partial deafferentation of the striatum (by cerebral hemitransection at mid-hypothalamic level) increased striatal TRH 2-3-fold, while lesions of the dorsal raphe did not significantly change striatal TRH. Thus TRH levels in rat striatum are closely regulated by dopaminergic and other neurotransmitter systems.",

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author = "Spindel, \{Eliot R.\} and Pettibone, \{Douglas J.\} and Wurtman, \{Richard J.\}",

note = "Funding Information: These studies were supported by grants from the International Life Sciences Institute and the National Institutes of Health. We thank Dr. Franz Hefti for advice on stereotaxic procedures, Dr. Arthur Schlossberg for performing the raphe lesions and Dr. Alan Sved for the serotonin analysis.",

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T2 - Modification by drugs and lesions

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N1 - Funding Information: These studies were supported by grants from the International Life Sciences Institute and the National Institutes of Health. We thank Dr. Franz Hefti for advice on stereotaxic procedures, Dr. Arthur Schlossberg for performing the raphe lesions and Dr. Alan Sved for the serotonin analysis.

PY - 1981/7/20

Y1 - 1981/7/20

N2 - Two hours after injection, d-amphetamine sulfate (10 mg/kg, i.p.) lowered thyrotropin-releasing hormone (TRH) levels in rat striatum by 50%, but produced no significant changes in the TRH contents of hypothalamus, septum, brain stem or preoptic area. The effect peaked 2 h after amphetamine injection and declined slowly thereafter. The amphetamine-induced decrease in striatal TRH could be blocked by pretreatment with haloperidol or α-methyltyrosine, or by production of a 6-hydroxydopamine lesion in the ipsilateral substantia nigra. Amphetamine did not act by inhibiting protein synthesis in as much as cycloheximide did not similarly decrease striatal TRH. Kainic acid injected into the striatum lowered TRH by 30% after 5 days. In contrast, partial deafferentation of the striatum (by cerebral hemitransection at mid-hypothalamic level) increased striatal TRH 2-3-fold, while lesions of the dorsal raphe did not significantly change striatal TRH. Thus TRH levels in rat striatum are closely regulated by dopaminergic and other neurotransmitter systems.

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Thyrotropin-releasing hormone (TRH) content of rat striatum: Modification by drugs and lesions

Abstract

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