Abstract
Weanling male Sprague-Dawley rats were fed a diet containing 0.4 parts/ 106 zinc and controls were fed an identical diet supplemented with 40 parts/ 106 zinc. After 9, 18 and 27 days of zinc deficiency, specimens were excised from cheek epithelium and processed for transmission electron microscopy to study the concentration of membrane-coating granules (MCG). Their concentration was increased in the granular-cell layers of the zinc-deficient epithelium and became significantly greater after 18 and 27 days than 9 days of deficiency. MCGs appeared in the parakeratinized layers of zinc-deficient epithelium and their concentration became significantly greater after 27 days in comparison with 9 and 18 days of deficiency. Thus the intracellular retention of MCGs was increased in the granular and parakeratinized layers with the increase in time of zinc deficiency.
Original language | English (US) |
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Pages (from-to) | 717-722 |
Number of pages | 6 |
Journal | Archives of Oral Biology |
Volume | 40 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1995 |
Externally published | Yes |
Keywords
- granular cells
- keratinization
- rat buccal cheek epithelium
- time-related changes
- zinc deficiency
ASJC Scopus subject areas
- Otorhinolaryngology
- General Dentistry
- Cell Biology