Time-resolved photon emission from layered turbid media

Andreas H. Hielscher; Hanli Liu; Britton Chance; Frank K. Tittel; Steven L. Jacques

doi:10.1364/AO.35.000719

Time-resolved photon emission from layered turbid media

Andreas H. Hielscher, Hanli Liu, Britton Chance, Frank K. Tittel, Steven L. Jacques

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

We present numerical and experimental results of time-resolved emission profiles from various layered turbid media. Numerical solutions determined by time-resolved Monte Carlo simulations are compared with measurements on layered-tissue phantoms made from gelatin. In particular, we show that in certain cases the effects of the upper layers can be eliminated. As a practical example, these results are used to analyze in vivo measurements on the human head. This demonstrates the influence of skin, skull, and meninges on the determination of the blood oxygenation in the brain.

Original language	English (US)
Pages (from-to)	719-728
Number of pages	10
Journal	Applied Optics
Volume	35
Issue number	4
DOIs	https://doi.org/10.1364/AO.35.000719
State	Published - Feb 1 1996
Externally published	Yes

Keywords

Blood oxygenation
Brain
Diffusion theory
Monte Carlo simulation
Multilayer
Photon counting
Photon migration
Reflectance
Scattering
Time-resolved
Tissue phantom

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Engineering (miscellaneous)
Electrical and Electronic Engineering

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10.1364/AO.35.000719

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title = "Time-resolved photon emission from layered turbid media",

abstract = "We present numerical and experimental results of time-resolved emission profiles from various layered turbid media. Numerical solutions determined by time-resolved Monte Carlo simulations are compared with measurements on layered-tissue phantoms made from gelatin. In particular, we show that in certain cases the effects of the upper layers can be eliminated. As a practical example, these results are used to analyze in vivo measurements on the human head. This demonstrates the influence of skin, skull, and meninges on the determination of the blood oxygenation in the brain.",

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T1 - Time-resolved photon emission from layered turbid media

AU - Hielscher, Andreas H.

AU - Liu, Hanli

AU - Chance, Britton

AU - Tittel, Frank K.

AU - Jacques, Steven L.

PY - 1996/2/1

Y1 - 1996/2/1

N2 - We present numerical and experimental results of time-resolved emission profiles from various layered turbid media. Numerical solutions determined by time-resolved Monte Carlo simulations are compared with measurements on layered-tissue phantoms made from gelatin. In particular, we show that in certain cases the effects of the upper layers can be eliminated. As a practical example, these results are used to analyze in vivo measurements on the human head. This demonstrates the influence of skin, skull, and meninges on the determination of the blood oxygenation in the brain.

AB - We present numerical and experimental results of time-resolved emission profiles from various layered turbid media. Numerical solutions determined by time-resolved Monte Carlo simulations are compared with measurements on layered-tissue phantoms made from gelatin. In particular, we show that in certain cases the effects of the upper layers can be eliminated. As a practical example, these results are used to analyze in vivo measurements on the human head. This demonstrates the influence of skin, skull, and meninges on the determination of the blood oxygenation in the brain.

KW - Blood oxygenation

KW - Brain

KW - Diffusion theory

KW - Monte Carlo simulation

KW - Multilayer

KW - Photon counting

KW - Photon migration

KW - Reflectance

KW - Scattering

KW - Time-resolved

KW - Tissue phantom

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JO - Applied Optics

JF - Applied Optics

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Time-resolved photon emission from layered turbid media

Abstract

Keywords

ASJC Scopus subject areas

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