Abstract
Chronic treatment of rats with morphine caused tolerance to the membrane hyperpolarizing action of morphine in single locus coeruleus neurons in vitro. Tolerance was less pronounced for Try-D-Ala-Gly-MePhe-Gly-ol (DAGO) than for normorphine. No changes were found in affinity of naloxone for mu-receptors on these neurons, nor in the properties of the potassium conductance increase caused by mu-receptor activation. These results suggest that the mechanisms underlying tolerance involve either a reduction of the number of mu-receptors on each cell, or a reduced coupling of mu-receptors to potassium channels.
Original language | English (US) |
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Pages (from-to) | 591-594 |
Number of pages | 4 |
Journal | NIDA research monograph |
Volume | 75 |
State | Published - 1986 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine (miscellaneous)