Topical chemotherapy for ocular surface squamous neoplasia

Afshan A. Nanji, Fouad E. Sayyad, Carol L. Karp

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations


PURPOSE OF REVIEW: Ocular surface squamous neoplasia (OSSN) is an umbrella term for a spectrum of epithelial dysplasias of the cornea, conjunctiva, and limbus. Treatment for OSSN has historically been surgery, but nonsurgical interventions have been increasingly adopted. Advantages of medical treatments include the ability to treat the entire ocular surface and prevention of surgical complications. RECENT FINDINGS: The primary medical treatments for OSSN include mitomycin C, 5-fluorouracil, and interferon α2b. Mitomycin C has been shown in studies to be highly effective but has short-term and long-term side-effects that may be intolerable. 5-Fluorouracil and interferon α2b have been found to be similar in efficacy to mitomycin, with interferon being extremely well tolerated in the majority of patients. Most recently, other chemotherapeutic agents have been tried for OSSN including antivascular endothelial growth factor agents and vitamin A. The data regarding these latter treatment strategies are still limited. SUMMARY: An understanding of the recent literature, with respect to the efficacy, advantages, and disadvantages of the various therapies for OSSN will allow us to tailor treatment to each patient.

Original languageEnglish (US)
Pages (from-to)336-342
Number of pages7
JournalCurrent opinion in ophthalmology
Issue number4
StatePublished - Jul 2013
Externally publishedYes


  • 5-fluorouracil
  • interferon
  • mitomycin C
  • ocular surface squamous neoplasia
  • topical chemotherapy

ASJC Scopus subject areas

  • Ophthalmology


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