Toward 20 T magnetic resonance for human brain studies: opportunities for discovery and neuroscience rationale

Thomas F. Budinger; Mark D. Bird; Lucio Frydman; Joanna R. Long; Thomas H. Mareci; William D. Rooney; Bruce Rosen; John F. Schenck; Victor D. Schepkin; A. Dean Sherry; Daniel K. Sodickson; Charles S. Springer; Keith R. Thulborn; Kamil Uğurbil; Lawrence L. Wald

doi:10.1007/s10334-016-0561-4

Toward 20 T magnetic resonance for human brain studies: opportunities for discovery and neuroscience rationale

Thomas F. Budinger, Mark D. Bird, Lucio Frydman, Joanna R. Long, Thomas H. Mareci, William D. Rooney, Bruce Rosen, John F. Schenck, Victor D. Schepkin, A. Dean Sherry, Daniel K. Sodickson, Charles S. Springer, Keith R. Thulborn, Kamil Uğurbil, Lawrence L. Wald

Advanced Imaging Research Center

Research output: Contribution to journal › Review article › peer-review

70 Scopus citations

Abstract

An initiative to design and build magnetic resonance imaging (MRI) and spectroscopy (MRS) instruments at 14 T and beyond to 20 T has been underway since 2012. This initiative has been supported by 22 interested participants from the USA and Europe, of which 15 are authors of this review. Advances in high temperature superconductor materials, advances in cryocooling engineering, prospects for non-persistent mode stable magnets, and experiences gained from large-bore, high-field magnet engineering for the nuclear fusion endeavors support the feasibility of a human brain MRI and MRS system with 1 ppm homogeneity over at least a 16-cm diameter volume and a bore size of 68 cm. Twelve neuroscience opportunities are presented as well as an analysis of the biophysical and physiological effects to be investigated before exposing human subjects to the high fields of 14 T and beyond.

Original language	English (US)
Pages (from-to)	617-639
Number of pages	23
Journal	Magnetic Resonance Materials in Physics, Biology and Medicine
Volume	29
Issue number	3
DOIs	https://doi.org/10.1007/s10334-016-0561-4
State	Published - Jun 1 2016

Keywords

Diffusion tensor imaging
High temperature superconductors
Human brain chemistry
Magnetic field physiologic effects
Magnetic resonance imaging
Parallel transmit and receive strategies
Ultrahigh magnetic fields

ASJC Scopus subject areas

Biophysics
Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

Access to Document

10.1007/s10334-016-0561-4

Cite this

Budinger, T. F., Bird, M. D., Frydman, L., Long, J. R., Mareci, T. H., Rooney, W. D., Rosen, B., Schenck, J. F., Schepkin, V. D., Sherry, A. D., Sodickson, D. K., Springer, C. S., Thulborn, K. R., Uğurbil, K., & Wald, L. L. (2016). Toward 20 T magnetic resonance for human brain studies: opportunities for discovery and neuroscience rationale. Magnetic Resonance Materials in Physics, Biology and Medicine, 29(3), 617-639. https://doi.org/10.1007/s10334-016-0561-4

Budinger, TF, Bird, MD, Frydman, L, Long, JR, Mareci, TH, Rooney, WD, Rosen, B, Schenck, JF, Schepkin, VD, Sherry, AD, Sodickson, DK, Springer, CS, Thulborn, KR, Uğurbil, K & Wald, LL 2016, 'Toward 20 T magnetic resonance for human brain studies: opportunities for discovery and neuroscience rationale', Magnetic Resonance Materials in Physics, Biology and Medicine, vol. 29, no. 3, pp. 617-639. https://doi.org/10.1007/s10334-016-0561-4

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