Abstract
AL amyloidosis is a plasma cell disorder in which tissue deposition of immunoglobulin light chains leads to organ dysfunction. Recent reports of high-dose therapy with autologous stem cell transplantation for amyloidosis suggest higher response rates and extended survival compared to those seen with conventional chemotherapy. However, substantial treatment-related toxicity has been observed. This case series describes our institutional experience with autologous transplantation in four patients with amyloidosis with an emphasis on unique gastrointestinal toxicities, including toxic megacolon.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 279-285 |
| Number of pages | 7 |
| Journal | Bone marrow transplantation |
| Volume | 30 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2002 |
Keywords
- AL amyloidosis
- High-dose chemotherapy
- Stem cell transplantation
- Toxic megacolon
ASJC Scopus subject areas
- Hematology
- Transplantation
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