Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation

Mathieu Gissot; Sang Woon Choi; Reid F. Thompson; John M. Greally; Kami Kim

doi:10.1128/EC.00448-07

Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation

Mathieu Gissot, Sang Woon Choi, Reid F. Thompson, John M. Greally, Kami Kim

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Epigenetic factors play a role in the expression of virulence traits in Apicomplexa. Apicomplexan genomes encode putative DNA cytosine methylation enzymes. To assess the presence of cytosine methylation of Toxoplasma gondii and Cryptosporidium parvum DNA, we used mass spectrometry analysis and confirmed that these organisms lack detectable methylcytosine in their DNA.

Original language	English (US)
Pages (from-to)	537-540
Number of pages	4
Journal	Eukaryotic Cell
Volume	7
Issue number	3
DOIs	https://doi.org/10.1128/EC.00448-07
State	Published - Mar 2008
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Molecular Biology

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title = "Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation",

abstract = "Epigenetic factors play a role in the expression of virulence traits in Apicomplexa. Apicomplexan genomes encode putative DNA cytosine methylation enzymes. To assess the presence of cytosine methylation of Toxoplasma gondii and Cryptosporidium parvum DNA, we used mass spectrometry analysis and confirmed that these organisms lack detectable methylcytosine in their DNA.",

author = "Mathieu Gissot and Choi, {Sang Woon} and Thompson, {Reid F.} and Greally, {John M.} and Kami Kim",

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AU - Gissot, Mathieu

AU - Choi, Sang Woon

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AU - Greally, John M.

AU - Kim, Kami

PY - 2008/3

Y1 - 2008/3

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AB - Epigenetic factors play a role in the expression of virulence traits in Apicomplexa. Apicomplexan genomes encode putative DNA cytosine methylation enzymes. To assess the presence of cytosine methylation of Toxoplasma gondii and Cryptosporidium parvum DNA, we used mass spectrometry analysis and confirmed that these organisms lack detectable methylcytosine in their DNA.

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Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation

Abstract

ASJC Scopus subject areas

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