Transient outgrowth from retinae implanted in the neonatal rat cerebral cortex

Mark Hankin; Ann Jervie Sefton; Raymond D. Lund

doi:10.1016/0165-3806(93)90075-L

Transient outgrowth from retinae implanted in the neonatal rat cerebral cortex

Mark Hankin, Ann Jervie Sefton, Raymond D. Lund

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Retinae placed in the cortex of neonatal rodents show substantial outgrowth, both along the subpial margin and within the cortical white matter, which is not sustained beyond 6 days post-transplantation. These results, in combination with previous studies, suggest that optic axon outgrowth is sustained for a finite period, after which it requires target-derived influences for its long-term maintenance.

Original language	English (US)
Pages (from-to)	146-150
Number of pages	5
Journal	Developmental Brain Research
Volume	75
Issue number	1
DOIs	https://doi.org/10.1016/0165-3806(93)90075-L
State	Published - Sep 17 1993
Externally published	Yes

Keywords

Axonal guidance
M6 antibody
Molecular layer
Optic axon
Transplantation
White matter

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/0165-3806(93)90075-L

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title = "Transient outgrowth from retinae implanted in the neonatal rat cerebral cortex",

abstract = "Retinae placed in the cortex of neonatal rodents show substantial outgrowth, both along the subpial margin and within the cortical white matter, which is not sustained beyond 6 days post-transplantation. These results, in combination with previous studies, suggest that optic axon outgrowth is sustained for a finite period, after which it requires target-derived influences for its long-term maintenance.",

keywords = "Axonal guidance, M6 antibody, Molecular layer, Optic axon, Transplantation, White matter",

author = "Mark Hankin and Sefton, {Ann Jervie} and Lund, {Raymond D.}",

note = "Funding Information: We would like to thank Bob Zatezalo and Ava Smetanka (University of Pittsburgh) and Jane Reese (Medical College of Ohio) for their technical assistance. We are grateful to Robert W. Rhoades for his thoughtful comments on the manuscript. This work was supported by grants from NIH (NS26777 to M.H. and EY05308 to R.D.L.), the Burroughs Wellcome Fund (M.H.), and Action Research (R.D.L.).",

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doi = "10.1016/0165-3806(93)90075-L",

language = "English (US)",

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T1 - Transient outgrowth from retinae implanted in the neonatal rat cerebral cortex

AU - Hankin, Mark

AU - Sefton, Ann Jervie

AU - Lund, Raymond D.

N1 - Funding Information: We would like to thank Bob Zatezalo and Ava Smetanka (University of Pittsburgh) and Jane Reese (Medical College of Ohio) for their technical assistance. We are grateful to Robert W. Rhoades for his thoughtful comments on the manuscript. This work was supported by grants from NIH (NS26777 to M.H. and EY05308 to R.D.L.), the Burroughs Wellcome Fund (M.H.), and Action Research (R.D.L.).

PY - 1993/9/17

Y1 - 1993/9/17

N2 - Retinae placed in the cortex of neonatal rodents show substantial outgrowth, both along the subpial margin and within the cortical white matter, which is not sustained beyond 6 days post-transplantation. These results, in combination with previous studies, suggest that optic axon outgrowth is sustained for a finite period, after which it requires target-derived influences for its long-term maintenance.

AB - Retinae placed in the cortex of neonatal rodents show substantial outgrowth, both along the subpial margin and within the cortical white matter, which is not sustained beyond 6 days post-transplantation. These results, in combination with previous studies, suggest that optic axon outgrowth is sustained for a finite period, after which it requires target-derived influences for its long-term maintenance.

KW - Axonal guidance

KW - M6 antibody

KW - Molecular layer

KW - Optic axon

KW - Transplantation

KW - White matter

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Transient outgrowth from retinae implanted in the neonatal rat cerebral cortex

Abstract

Keywords

ASJC Scopus subject areas

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