Abstract
Inherited retinal and choroidal degenerations account for a significant portion of blindness in children and young adults. This article reviews the current status and future prospects for the treatment of these disorders. Current treatment strategies include nutritional intervention for gyrate atrophy of the choroid and retina with hyperornithinemia, abetalipoproteinemia, and Refsum's disease, as well as vitamin A supplementation for retinitis pigmentosa. Future therapeutic prospects include gene therapy for both recessive and dominant disease, secondary gene-based therapies, such as pharmaceutic gene product replacement and treatment with survival factors, anti-apoptotic agents, and calcium blockers, and, finally, stem cell therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 583-593 |
| Number of pages | 11 |
| Journal | Ophthalmology Clinics of North America |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 2003 |
Funding
This work was supported by a grant from the Foundation Fighting Blindness, Inc., and Research to Prevent Blindness.
| Funders |
|---|
| Foundation Fighting Blindness |
| Research to Prevent Blindness |
ASJC Scopus subject areas
- Ophthalmology
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