Trisomy 13 and the risk of gestational hypertensive disorders: a population-based study

Sarah K. Dotters-Katz, Whitney M. Humphrey, Kayli L. Senz, Vanessa R. Lee, Brian Shaffer, Jeffrey A. Kuller, Aaron B. Caughey

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Purpose: To describe the rate and severity of gestational hypertensive disorders (GHDs) in pregnancies complicated by trisomy 13 (T13). Materials and methods: Retrospective cohort study of singleton deliveries in California from 2005 to 2008 using vital statistics and ICD-9 data. We were interested in gestational hypertension (gHTN), preeclampsia with and without severe features (sPREX and PREX), and gestational age at delivery. Pregnancies and maternal complications affected by prenatally diagnosed T13 were compared to unaffected pregnancies. Regression models were used to compute adjusted odds ratios for pregnancy outcomes by T13 status. Results: Of the 2,029,004 deliveries, 142 women had prenatally diagnosed T13. A diagnosis of GHD occurred in 26.8% of the T13 pregnancies versus 6% of the non-T13 pregnancies (p <.001). This remained true for gHTN (9.2% versus 3.2%, p=.001), PREX (12% versus 2.2%, p <.001), and sPREX (8.5% versus 0.9%, p <.001). After adjusting for confounders, T13 pregnancies were 6.3-times more likely to be affected by GHD, and 12.5-times more likely to have sPREX. Delivery <37 and <32 weeks in the setting of GHD was 14.1-times and 11.2-times likely among women with T13. Conclusions: Women with T13 pregnancies were significantly more likely to have gHTN, preeclampsia, sPREX, and to deliver <32 weeks.

Original languageEnglish (US)
Pages (from-to)1951-1955
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number15
StatePublished - Aug 3 2018


  • Patau Syndrome
  • Trisomy 13
  • gestational hypertension
  • maternal outcomes
  • preeclampsia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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