TRPV4 and hypotonic stress

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


TRPV4 was identified as the mammalian homologue of the C. elegans osmosensory channel protein, OSM-9. This nonselective cation channel is activated in vitro by even modest degrees of hypotonic cell swelling. Its expression in the mammalian central nervous system and kidney suggests a role in systemic osmoregulation-a view borne out by detailed balance studies in TRPV4-null mice. Two distinct mechanisms have been described through which TRPV4 may be activated by hypotonicity: one involves the SRC family of nonreceptor protein tyrosine kinases, while the other is mediated via arachidonic acid metabolites.

Original languageEnglish (US)
Title of host publicationMolecular Sensors for Cardiovascular Homeostasis
PublisherSpringer US
Number of pages11
ISBN (Print)0387475281, 9780387475288
StatePublished - 2007

ASJC Scopus subject areas

  • Medicine(all)


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