Tumefactive Demyelinating Lesions in Multiple Sclerosis and Associated Disorders

Meredith C. Frederick, Michelle Cameron

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Tumefactive demyelinating lesions are rare consequences of central nervous system (CNS) idiopathic inflammatory demyelinating diseases. Tumefactive demyelinating lesions pose a diagnostic challenge because they can mimic tumors and abscesses and because they can be caused by a heterogeneous range of disorders. This article reviews the recent literature on the clinical presentation; radiographic features; prognosis; and management of tumefactive demyelinating lesions in multiple sclerosis, acute demyelinating encephalomyelitis, neuromyelitis optica, and the rare variants of multiple sclerosis including Schilder’s disease, Marburg acute multiple sclerosis, and Balo’s concentric sclerosis.

Original languageEnglish (US)
Article number26
Pages (from-to)1-7
Number of pages7
JournalCurrent Neurology and Neuroscience Reports
Issue number3
StatePublished - Mar 1 2016


  • Balo’s concentric sclerosis
  • Marburg
  • Schilder’s disease
  • Tumefactive multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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