Tumor-associated macrophages press the angiogenic switch in breast cancer

Elaine Y. Lin, Jeffrey W. Pollard

Research output: Contribution to journalReview articlepeer-review

371 Scopus citations


The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors.

Original languageEnglish (US)
Pages (from-to)5064-5066
Number of pages3
JournalCancer Research
Issue number11
StatePublished - Jun 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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