@article{6da73d93642f4e7abd7905b964aeef0f,
title = "TumorMap: Exploring the molecular similarities of cancer samples in an interactive portal",
abstract = "Vast amounts of molecular data are being collected on tumor samples, which provide unique opportunities for discovering trends within and between cancer subtypes. Such cross-cancer analyses require computational methods that enable intuitive and interactive browsing of thousands of samples based on their molecular similarity. We created a portal called TumorMap to assist in exploration and statistical interrogation of high-dimensional complex {"}omics{"} data in an interactive and easily interpretable way. In the TumorMap, samples are arranged on a hexagonal grid based on their similarity to one another in the original genomic space and are rendered with Google's Map technology. While the important feature of this public portal is the ability for the users to build maps from their own data, we pre-built genomic maps from several previously published projects. We demonstrate the utility of this portal by presenting results obtained from The Cancer Genome Atlas project data.",
author = "Yulia Newton and Novak, {Adam M.} and Teresa Swatloski and McColl, {Duncan C.} and Sahil Chopra and Kiley Graim and Weinstein, {Alana S.} and Robert Baertsch and Salama, {Sofie R.} and Kyle Ellrott and Manu Chopra and Goldstein, {Theodore C.} and David Haussler and Olena Morozova and Stuart, {Joshua M.}",
note = "Funding Information: Grant Support This work was supported by National Cancer Institute grants U24-CA143858 (to D. Haussler and J.M. Stuart) and 1R01CA180778 (to J.M. Stuart), National Human Genome Research Institute (5U54HG006097 to J.M. Stuart), National Institute for General Medical Sciences (5R01GM109031 to J.M. Stuart), National Science Foundation Office of Cyberinfrastructure CAREER (0845783 to J.M. Stuart), and Prostate Cancer Foundation (to J.M. Stuart). J.M. Stuart is supported by a Stand Up To Cancer – Prostate Cancer Foundation Prostate Dream Team Translational Research Grant (SU2C-AACR-DT0812). This research Grant is made possible by the generous support of the Movember Foundation. Stand Up To Cancer is a program of the Entertainment Industry Foundation. Research grants are administered by the American Association for Cancer Research, the Scientific Partner of SU2C. This work was supported by the St. Baldricks Foundation Treehouse Childhood Cancer Project under award number 427053, the University of California California Precision Medicine Initiative: California Kids Cancer Comparison under award number OPR014109, and the Alex's Lemonade Stand Foundation Innovation Award. The content is solely the responsibility of the authors and does not necessarily represent the official views of our sponsors. Funding Information: This work was supported by National Cancer Institute grants U24-CA143858 (to D. Haussler and J.M. Stuart) and 1R01CA180778 (to J.M. Stuart), National Human Genome Research Institute (5U54HG006097 to J.M. Stuart), National Institute for General Medical Sciences (5R01GM109031 to J.M. Stuart), National Science Foundation Office of Cyberinfrastructure CAREER (0845783 to J.M. Stuart), and Prostate Cancer Foundation (to J.M. Stuart). J.M. Stuart is supported by a Stand Up To Cancer – Prostate Cancer Foundation Prostate Dream Team Translational Research Grant (SU2C-AACR-DT0812). This research Grant is made possible by the generous support of the Movember Foundation. Stand Up To CancerisaprogramoftheEntertainmentIndustryFoundation.Researchgrantsare administered by the American Association for Cancer Research, the Scientific Partner of SU2C. This work was supported by the St. Baldricks Foundation TreehouseChildhoodCancerProjectunderawardnumber427053,theUniversity of California California Precision Medicine Initiative: California Kids Cancer Comparison under award number OPR014109, and the Alex's Lemonade Stand Foundation Innovation Award. The content is solely the responsibility of the authors and does not necessarily represent the official views of our sponsors. Publisher Copyright: {\textcopyright} 2017 American Association for Cancer Research.",
year = "2017",
month = nov,
day = "1",
doi = "10.1158/0008-5472.CAN-17-0580",
language = "English (US)",
volume = "77",
pages = "e111--e114",
journal = "Cancer Research",
issn = "0008-5472",
number = "21",
}