Tumors of the anterior skull base

Michael E. Ivan, Seunggu J. Han, Manish K. Aghi

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


A variety of histologic tumor types are present in the anterior skull base. Primary tumors of this area may be derived from the bone, paranasal sinuses, nasopharynx, dura, cranial nerves, pituitary gland and brain. Symptoms are caused mostly through mass effect but, if the tumor becomes aggressive, also through invasion. Selection of surgical approaches to the anterior skull base is based upon balancing risk reduction with maximizing extent of resection. Here we review a spectrum of neoplastic entities found in the anterior skull base in adults and discuss clinical and radiographic presentation, treatment options, and outcomes. Surgical resection remains the mainstay in treatment of these tumors, particularly in the hands of experienced surgeons exercising proper patient and case selection.

Original languageEnglish (US)
Pages (from-to)425-438
Number of pages14
JournalExpert Review of Neurotherapeutics
Issue number4
StatePublished - Apr 2014
Externally publishedYes


  • Anterior skull base
  • Craniopharyngioma
  • Endonasal surgery
  • Endoscopic surgery
  • Esthesioneuroblastomas
  • Meningioma
  • Minimally invasive surgery
  • Non-neuroendocrine sinonasopharyngeal tumors
  • Pituitary adenoma
  • Radiotherapy
  • Sinonasal undifferentiated carcinoma

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)


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