@article{1d5f9af6e46048898e6828d622262729,
title = "Two myeloid leukemia cases with rare FLT3 fusions",
abstract = "Genetic rearrangements involving FLT3 are rare and only recently have been detected in myeloid/lymphoid neoplasms associated with eosinophilia (MLN-eos) and chronic myeloproliferative disorders. Here we report two cases with FLT3 fusions in patients demonstrating mixed features of myelodysplastic/myeloproliferative neoplasms. In the first case, FLT3 was fused with a new fusion partner MYO18A in a patient with marrow features most consistent with atypical chronic myeloid leukemia; the second case involving ETV6-FLT3 fusion was observed in a case with bone marrow features most consistent with chronic myelomonocytic leukemia. Notably, we observed that samples from both patients demonstrated FLT3 inhibitor (quizartinib and sorafenib) sensitivity in ex vivo drug screening assay.",
author = "Haijiao Zhang and Aleksandra Paliga and Evie Hobbs and Stephen Moore and Susan Olson and Nicola Long and Dao, {Kim Hien T.} and Tyner, {Jeffrey W.}",
note = "Funding Information: The authors thank Beth Wilmot, Daniel Bottomly, and Shannon K. McWeeney for the RNA-seq fusion analysis. The authors thank Kara Johnson for general help. J.W.T. was supported by The Leukemia & Lymphoma Society, the V Foundation for Cancer Research, the Gabrielle's Angel Foundation for Cancer Research, and the National Cancer Institute (1R01CA183947-01, 1U01CA217862, 1U54CA224019, 1U01CA214116). H.Z. received the Medical Research Foundation (MRF) grant and Collins Trust Award. Funding Information: by The Leukemia & Lymphoma Society, the V Foundation for Cancer Research, the Gabrielle{\textquoteright}s Angel Foundation for Cancer Research, and the National Cancer Institute (1R01CA183947-01, 1U01CA217862, 1U54CA224019, 1U01CA214116). H.Z. received the Medical Research Foundation (MRF) grant and Collins Trust Award. Publisher Copyright: {\textcopyright} 2018 Zhang et al.",
year = "2018",
month = dec,
doi = "10.1101/mcs.a003079",
language = "English (US)",
volume = "4",
journal = "Cold Spring Harbor Molecular Case Studies",
issn = "2373-2873",
publisher = "Cold Spring Harbor Laboratory Press",
number = "6",
}