Two-step insertion at the SecY translocon

Soo Jung Kim, William R. Skach

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


SecY and Sec61 translocons mediate the orderly insertion of transmembrane segments into the lipid bilayer during membrane-protein biogenesis. Reporting in this issue, Ismail et al. now use a SecM-based molecular force sensor to show that the translocon exerts a pulling force on the nascent chain that is capable of mechanical action at two distinct stages of the insertion process.

Original languageEnglish (US)
Pages (from-to)975-977
Number of pages3
JournalNature Structural and Molecular Biology
Issue number10
StatePublished - Oct 2012
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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