Two-step insertion at the SecY translocon

Soo Jung Kim; William R. Skach

doi:10.1038/nsmb.2402

Two-step insertion at the SecY translocon

Soo Jung Kim, William R. Skach

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

SecY and Sec61 translocons mediate the orderly insertion of transmembrane segments into the lipid bilayer during membrane-protein biogenesis. Reporting in this issue, Ismail et al. now use a SecM-based molecular force sensor to show that the translocon exerts a pulling force on the nascent chain that is capable of mechanical action at two distinct stages of the insertion process.

Original language	English (US)
Pages (from-to)	975-977
Number of pages	3
Journal	Nature Structural and Molecular Biology
Volume	19
Issue number	10
DOIs	https://doi.org/10.1038/nsmb.2402
State	Published - Oct 2012
Externally published	Yes

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1038/nsmb.2402

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Two-step insertion at the SecY translocon

Abstract

ASJC Scopus subject areas

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