Ultrasound elastography: is there a shear wave speed cutoff for pediatric liver fibrosis and inflammation?

Andrew Phelps; Raga Ramachandran; Jesse Courtier; Emily Perito; Philip Rosenthal; John D. MacKenzie

doi:10.1016/j.clinimag.2016.10.012

Ultrasound elastography: is there a shear wave speed cutoff for pediatric liver fibrosis and inflammation?

Andrew Phelps, Raga Ramachandran, Jesse Courtier, Emily Perito, Philip Rosenthal, John D. MacKenzie

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Objective The objective was to identify a shear wave speed (SWS) cutoff in pediatric liver disease to detect fibrosis and inflammation. Methods We performed an institutional-review-board-approved prospective study of liver SWS in 41 children undergoing liver biopsy. Results In patients without inflammation, SWS was higher when fibrosis was present compared to when fibrosis was not present (average SWS 1.8 vs. 1.4 m/s, respectively, P=.02). A SWS cutoff of 1.7 m/s had 100% positive predictive value and 24% negative predictive value for detecting fibrosis or inflammation. Conclusion Point shear wave elastography is an insufficient stand-alone screening tool for liver fibrosis and inflammation in a heterogeneous patient population.

Original language	English (US)
Pages (from-to)	95-100
Number of pages	6
Journal	Clinical Imaging
Volume	41
DOIs	https://doi.org/10.1016/j.clinimag.2016.10.012
State	Published - Jan 1 2017
Externally published	Yes

Keywords

ARFI
Elastography
Shear wave speed
pSWE

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1016/j.clinimag.2016.10.012

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title = "Ultrasound elastography: is there a shear wave speed cutoff for pediatric liver fibrosis and inflammation?",

abstract = "Objective The objective was to identify a shear wave speed (SWS) cutoff in pediatric liver disease to detect fibrosis and inflammation. Methods We performed an institutional-review-board-approved prospective study of liver SWS in 41 children undergoing liver biopsy. Results In patients without inflammation, SWS was higher when fibrosis was present compared to when fibrosis was not present (average SWS 1.8 vs. 1.4 m/s, respectively, P=.02). A SWS cutoff of 1.7 m/s had 100% positive predictive value and 24% negative predictive value for detecting fibrosis or inflammation. Conclusion Point shear wave elastography is an insufficient stand-alone screening tool for liver fibrosis and inflammation in a heterogeneous patient population.",

keywords = "ARFI, Elastography, Shear wave speed, pSWE",

author = "Andrew Phelps and Raga Ramachandran and Jesse Courtier and Emily Perito and Philip Rosenthal and MacKenzie, {John D.}",

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doi = "10.1016/j.clinimag.2016.10.012",

language = "English (US)",

volume = "41",

pages = "95--100",

journal = "Clinical Imaging",

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TY - JOUR

T1 - Ultrasound elastography

T2 - is there a shear wave speed cutoff for pediatric liver fibrosis and inflammation?

AU - Phelps, Andrew

AU - Ramachandran, Raga

AU - Courtier, Jesse

AU - Perito, Emily

AU - Rosenthal, Philip

AU - MacKenzie, John D.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objective The objective was to identify a shear wave speed (SWS) cutoff in pediatric liver disease to detect fibrosis and inflammation. Methods We performed an institutional-review-board-approved prospective study of liver SWS in 41 children undergoing liver biopsy. Results In patients without inflammation, SWS was higher when fibrosis was present compared to when fibrosis was not present (average SWS 1.8 vs. 1.4 m/s, respectively, P=.02). A SWS cutoff of 1.7 m/s had 100% positive predictive value and 24% negative predictive value for detecting fibrosis or inflammation. Conclusion Point shear wave elastography is an insufficient stand-alone screening tool for liver fibrosis and inflammation in a heterogeneous patient population.

AB - Objective The objective was to identify a shear wave speed (SWS) cutoff in pediatric liver disease to detect fibrosis and inflammation. Methods We performed an institutional-review-board-approved prospective study of liver SWS in 41 children undergoing liver biopsy. Results In patients without inflammation, SWS was higher when fibrosis was present compared to when fibrosis was not present (average SWS 1.8 vs. 1.4 m/s, respectively, P=.02). A SWS cutoff of 1.7 m/s had 100% positive predictive value and 24% negative predictive value for detecting fibrosis or inflammation. Conclusion Point shear wave elastography is an insufficient stand-alone screening tool for liver fibrosis and inflammation in a heterogeneous patient population.

KW - ARFI

KW - Elastography

KW - Shear wave speed

KW - pSWE

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JO - Clinical Imaging

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Ultrasound elastography: is there a shear wave speed cutoff for pediatric liver fibrosis and inflammation?

Abstract

Keywords

ASJC Scopus subject areas

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