Understanding diverse TRPV1 signaling – an update [version 1; peer review: 4 approved]

Michael Andresen

doi:10.12688/f1000research.20795.1

Understanding diverse TRPV1 signaling – an update [version 1; peer review: 4 approved]

Michael Andresen

Physiology & Pharmacology

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

The transient receptor potential vanilloid 1 (TRPV1) is densely expressed in spinal sensory neurons as well as in cranial sensory neurons, including their central terminal endings. Recent work in the less familiar cranial sensory neurons, despite their many similarities with spinal sensory neurons, suggest that TRPV1 acts as a calcium channel to release a discrete population of synaptic vesicles. The modular and independent regulation of release offers new questions about nanodomain organization of release and selective actions of G protein–coupled receptors.

Original language	English (US)
Article number	1978
Journal	F1000Research
Volume	8
DOIs	https://doi.org/10.12688/f1000research.20795.1
State	Published - 2019

Keywords

Cranial nerve
NTS
Solitary tract nucleus
Synaptic transmission
TRPV1
Vagus
Visceral afferent

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.12688/f1000research.20795.1

Cite this

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title = "Understanding diverse TRPV1 signaling – an update [version 1; peer review: 4 approved]",

abstract = "The transient receptor potential vanilloid 1 (TRPV1) is densely expressed in spinal sensory neurons as well as in cranial sensory neurons, including their central terminal endings. Recent work in the less familiar cranial sensory neurons, despite their many similarities with spinal sensory neurons, suggest that TRPV1 acts as a calcium channel to release a discrete population of synaptic vesicles. The modular and independent regulation of release offers new questions about nanodomain organization of release and selective actions of G protein–coupled receptors.",

keywords = "Cranial nerve, NTS, Solitary tract nucleus, Synaptic transmission, TRPV1, Vagus, Visceral afferent",

author = "Michael Andresen",

note = "Funding Information: This work was supported by grants from the National Institutes of Health, HL-133505 (MCA). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung and Blood Institute or the NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: Grant information: This work was supported by grants from the National Institutes of Health, HL-133505 (MCA). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung and Blood Institute or the NIH. Publisher Copyright: {\textcopyright} 2019 Andresen M.",

year = "2019",

doi = "10.12688/f1000research.20795.1",

language = "English (US)",

volume = "8",

journal = "F1000Research",

issn = "2046-1402",

publisher = "F1000 Research Ltd.",

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T2 - 4 approved]

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N1 - Funding Information: This work was supported by grants from the National Institutes of Health, HL-133505 (MCA). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung and Blood Institute or the NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: Grant information: This work was supported by grants from the National Institutes of Health, HL-133505 (MCA). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung and Blood Institute or the NIH. Publisher Copyright: © 2019 Andresen M.

PY - 2019

Y1 - 2019

N2 - The transient receptor potential vanilloid 1 (TRPV1) is densely expressed in spinal sensory neurons as well as in cranial sensory neurons, including their central terminal endings. Recent work in the less familiar cranial sensory neurons, despite their many similarities with spinal sensory neurons, suggest that TRPV1 acts as a calcium channel to release a discrete population of synaptic vesicles. The modular and independent regulation of release offers new questions about nanodomain organization of release and selective actions of G protein–coupled receptors.

AB - The transient receptor potential vanilloid 1 (TRPV1) is densely expressed in spinal sensory neurons as well as in cranial sensory neurons, including their central terminal endings. Recent work in the less familiar cranial sensory neurons, despite their many similarities with spinal sensory neurons, suggest that TRPV1 acts as a calcium channel to release a discrete population of synaptic vesicles. The modular and independent regulation of release offers new questions about nanodomain organization of release and selective actions of G protein–coupled receptors.

KW - Cranial nerve

KW - NTS

KW - Solitary tract nucleus

KW - Synaptic transmission

KW - TRPV1

KW - Vagus

KW - Visceral afferent

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JO - F1000Research

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M1 - 1978

ER -

Understanding diverse TRPV1 signaling – an update [version 1; peer review: 4 approved]

Abstract

Keywords

ASJC Scopus subject areas

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