Unilateral testicular enlargement resulting from inapparent 21-hydroxylase deficiency

G. P. Chrousos, D. L. Loriaux, R. J. Sherins, G. B. Cutler

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


We report a case in which unilateral testicular enlargement was the only presenting sign in 21-hydroxylase deficiency of the 'acquired' or adult onset type. Measurement of plasma 17-hydroxyprogesterone throughout 24 hours revealed marked elevations, mostly between 0400 and 0700 hours. However, this steroid increased more than 18-fold 30 minutes following adrenocorticotropic hormone administration, confirming the diagnosis. Glucocorticoid therapy corrected the testicular enlargement. Inapparent 21-hydroxylase deficiency is a medically treatable cause of testicular enlargement that can be diagnosed by measurement of plasma 17-hydroxyprogesterone during a 30-minute adrenocorticotropic hormone stimulation test.

Original languageEnglish (US)
Pages (from-to)127-128
Number of pages2
JournalJournal of Urology
Issue number1
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Urology


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