Unmet need in rheumatology: Reports from the Targeted Therapies meeting 2019

Kevin L. Winthrop, Michael E. Weinblatt, Joan Bathon, Gerd R. Burmester, Philip J. Mease, Leslie Crofford, Vivian Bykerk, Maxime Dougados, James Todd Rosenbaum, Xavier Mariette, Joachim Sieper, Fritz Melchers, Bruce N. Cronstein, Ferry C. Breedveld, Joachim Kalden, Josef S. Smolen, Daniel Furst

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


Objectives To detail the greatest areas of unmet scientific and clinical needs in rheumatology. Methods The 21st annual international Advances in Targeted Therapies meeting brought together more than 100 leading basic scientists and clinical researchers in rheumatology, immunology, epidemiology, molecular biology and other specialties. During the meeting, breakout sessions were convened, consisting of 5 disease-specific groups with 20-30 experts assigned to each group based on expertise. Specific groups included: rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematosus and other systemic autoimmune rheumatic diseases. In each group, experts were asked to identify unmet clinical and translational research needs in general and then to prioritise and detail the most important specific needs within each disease area. Results Overarching themes across all disease states included the need to innovate clinical trial design with emphasis on studying patients with refractory disease, the development of trials that take into account disease endotypes and patients with overlapping inflammatory diseases, the need to better understand the prevalence and incidence of inflammatory diseases in developing regions of the world and ultimately to develop therapies that can cure inflammatory autoimmune diseases. Conclusions Unmet needs for new therapies and trial designs, particularly for those with treatment refractory disease, remain a top priority in rheumatology.

Original languageEnglish (US)
Pages (from-to)88-93
Number of pages6
JournalAnnals of the rheumatic diseases
Issue number1
StatePublished - Jan 1 2020


  • Sjögren's syndrome
  • ankylosing spondylitis
  • inflammatory myopathies
  • psoriatic arthritis
  • rheumatoid arthritis
  • spondyloarthritis
  • systemic lupus erythematosus
  • systemic sclerosis
  • vasculitis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology
  • General Biochemistry, Genetics and Molecular Biology


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