Update on animal models for HIV research

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Animal models for HIV research have been indispensible in fulfilling Koch's postulate and in exploring issues of viral infectivity and pathogenesis, sequence divergence, route(s) of acquisition, tissue distribution and tropism, immunogenicity and protection capacity of vaccine candidates, escape from adaptive immunity, and more. Did they fail to predict the efficacy of T-cell vaccines in humans? This article summarizes progress and status of models to inform and complement clinical work.

Original languageEnglish (US)
Pages (from-to)1994-1999
Number of pages6
JournalEuropean Journal of Immunology
Volume39
Issue number8
DOIs
StatePublished - Aug 2009

Keywords

  • AIDS
  • HIV-1
  • Nonhuman primate
  • SHIV
  • SIV

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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