TY - JOUR
T1 - Update on morphea
T2 - Part I. Epidemiology, clinical presentation, and pathogenesis
AU - Fett, Nicole
AU - Werth, Victoria P.
N1 - Funding Information:
Supported in part by a Merit Review Grant from the Department of Veterans Affairs Veterans Health Administration , Office of Research and Development , Biomedical Laboratory Research and Development , and by the National Institutes of Health (grant NIH K24-AR 02207 ) to Dr Werth.
PY - 2011/2
Y1 - 2011/2
N2 - Morphea, also known as localized scleroderma, is a rare fibrosing disorder of the skin and underlying tissues. Morphea is differentiated from systemic sclerosis based on the absence of sclerodactyly, Raynaud phenomenon, and nailfold capillary changes. Patients with morphea commonly have systemic symptoms, such as malaise, fatigue, arthralgias, and myalgias, as well as positive autoantibody serologies. However, involvement of morphea is almost uniformly limited to those tissues derived from the mesoderm. The underlying pathogenesis of morphea is incompletely understood at this time, but ultimately results in an imbalance of collagen production and destruction.
AB - Morphea, also known as localized scleroderma, is a rare fibrosing disorder of the skin and underlying tissues. Morphea is differentiated from systemic sclerosis based on the absence of sclerodactyly, Raynaud phenomenon, and nailfold capillary changes. Patients with morphea commonly have systemic symptoms, such as malaise, fatigue, arthralgias, and myalgias, as well as positive autoantibody serologies. However, involvement of morphea is almost uniformly limited to those tissues derived from the mesoderm. The underlying pathogenesis of morphea is incompletely understood at this time, but ultimately results in an imbalance of collagen production and destruction.
KW - autoimmune connective tissue disorder
KW - fibrosing disorders
KW - localized scleroderma
KW - morphea
KW - scleroderma
KW - systemic sclerosis
UR - http://www.scopus.com/inward/record.url?scp=78751561101&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78751561101&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2010.05.045
DO - 10.1016/j.jaad.2010.05.045
M3 - Review article
C2 - 21238823
AN - SCOPUS:78751561101
SN - 0190-9622
VL - 64
SP - 217
EP - 228
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 2
ER -