Uric acid correlates to oxidation and inflammation in opposite directions in women

Sheng Hui Wu; Xiao Ou Shu; Ginger Milne; Yong Bing Xiang; Xianglan Zhang; Qiuyin Cai; Sergio Fazio; MacRae F. Linton; Honglei Chen; Mark Purdue; Nathaniel Rothman; Yu Tang Gao; Wei Zheng; Gong Yang

doi:10.3109/1354750X.2015.1068852

Uric acid correlates to oxidation and inflammation in opposite directions in women

Sheng Hui Wu, Xiao Ou Shu, Ginger Milne, Yong Bing Xiang, Xianglan Zhang, Qiuyin Cai, Sergio Fazio, MacRae F. Linton, Honglei Chen, Mark Purdue, Nathaniel Rothman, Yu Tang Gao, Wei Zheng, Gong Yang

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Objective: To evaluate the association of uric acid (UA) levels with a panel of markers of oxidative stress and inflammation.Methods: Plasma UA levels, along with a panel of oxidative stress and inflammatory markers, were measured in 755 Chinese women.Results: Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F₂-isoprostanes and positively correlated to levels of inflammatory markers, such as C-reactive protein and some proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) in blood as well as prostaglandin E₂ metabolites in urine.Conclusions: Plasma UA levels correlate to oxidation and inflammation biomarkers in opposite directions in women.

Original language	English (US)
Pages (from-to)	225-231
Number of pages	7
Journal	Biomarkers
Volume	20
Issue number	4
DOIs	https://doi.org/10.3109/1354750X.2015.1068852
State	Published - May 19 2015
Externally published	Yes

Keywords

Biomarker
inflammation
oxidative stress
uric acid

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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10.3109/1354750X.2015.1068852

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title = "Uric acid correlates to oxidation and inflammation in opposite directions in women",

abstract = "Objective: To evaluate the association of uric acid (UA) levels with a panel of markers of oxidative stress and inflammation.Methods: Plasma UA levels, along with a panel of oxidative stress and inflammatory markers, were measured in 755 Chinese women.Results: Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F2-isoprostanes and positively correlated to levels of inflammatory markers, such as C-reactive protein and some proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) in blood as well as prostaglandin E2 metabolites in urine.Conclusions: Plasma UA levels correlate to oxidation and inflammation biomarkers in opposite directions in women.",

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author = "Wu, {Sheng Hui} and Shu, {Xiao Ou} and Ginger Milne and Xiang, {Yong Bing} and Xianglan Zhang and Qiuyin Cai and Sergio Fazio and Linton, {MacRae F.} and Honglei Chen and Mark Purdue and Nathaniel Rothman and Gao, {Yu Tang} and Wei Zheng and Gong Yang",

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doi = "10.3109/1354750X.2015.1068852",

language = "English (US)",

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T1 - Uric acid correlates to oxidation and inflammation in opposite directions in women

AU - Wu, Sheng Hui

AU - Shu, Xiao Ou

AU - Milne, Ginger

AU - Xiang, Yong Bing

AU - Zhang, Xianglan

AU - Cai, Qiuyin

AU - Fazio, Sergio

AU - Linton, MacRae F.

AU - Chen, Honglei

AU - Purdue, Mark

AU - Rothman, Nathaniel

AU - Gao, Yu Tang

AU - Zheng, Wei

AU - Yang, Gong

PY - 2015/5/19

Y1 - 2015/5/19

N2 - Objective: To evaluate the association of uric acid (UA) levels with a panel of markers of oxidative stress and inflammation.Methods: Plasma UA levels, along with a panel of oxidative stress and inflammatory markers, were measured in 755 Chinese women.Results: Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F2-isoprostanes and positively correlated to levels of inflammatory markers, such as C-reactive protein and some proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) in blood as well as prostaglandin E2 metabolites in urine.Conclusions: Plasma UA levels correlate to oxidation and inflammation biomarkers in opposite directions in women.

AB - Objective: To evaluate the association of uric acid (UA) levels with a panel of markers of oxidative stress and inflammation.Methods: Plasma UA levels, along with a panel of oxidative stress and inflammatory markers, were measured in 755 Chinese women.Results: Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F2-isoprostanes and positively correlated to levels of inflammatory markers, such as C-reactive protein and some proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) in blood as well as prostaglandin E2 metabolites in urine.Conclusions: Plasma UA levels correlate to oxidation and inflammation biomarkers in opposite directions in women.

KW - Biomarker

KW - inflammation

KW - oxidative stress

KW - uric acid

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Uric acid correlates to oxidation and inflammation in opposite directions in women

Abstract

Keywords

ASJC Scopus subject areas

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