Urokinase Infusion: Feasibility of Monitoring for Complications in a Non-Intensive Care Setting

William D. Routh, Clifton M. Tatum, Robert E. Barton, Gary M. Gross, Holt A. McDowell, Frederick S. Keller

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


In an effort to more effectively use critical care facilities and to reduce costs, during a 2½-year period, the condition of 32 patients who received 37 local intraarterial urokinase (UK) infusions was monitored in a nonintensive care unit (ICU) setting. Techniques of infusion, mean total dose of lytic agent used (1.7 million IU), and mean duration of infusion (22 hours) were similar to those reported previously in series of patients monitored in the ICU. Complete lysis (no angiographically detectable residual clot within the treated segment) was achieved in 28 of 37 infusions (76%). Major complications occurred during two infusions (5.4%). In 33 of the 37 cases, systemic heparin was administered during UK infusion. No cases of pericatheter thrombosis were encountered. At the authors’ institution, patients can be safely monitored during local UK infusion in a non-ICU setting without compromising effectiveness of therapy. This approach has resulted in enhanced cost-effectiveness of thrombolytic therapy and more effective use of critical care facilities.

Original languageEnglish (US)
Pages (from-to)69-72
Number of pages4
JournalJournal of Vascular and Interventional Radiology
Issue number1
StatePublished - 1991
Externally publishedYes


  • Arteries, extremities, 9*.458
  • Arteries, grafts and prostheses, 9*.452
  • Arteries, stenosis or obstruction, 9*.7214
  • ICU
  • PTFE
  • PTT
  • Thrombolysis, 9*.1274
  • UK
  • Urokinase, 9*.1274
  • intensive care unit
  • partial thromboplastin time
  • polytetrafluoroethylene
  • urokinase

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Urokinase Infusion: Feasibility of Monitoring for Complications in a Non-Intensive Care Setting'. Together they form a unique fingerprint.

Cite this