Utility of magnetization prepared GRE MRI for the detection of focal liver lesions

Thomas C. Winter; Patrick C. Freeny; Hanh V. Nghiem; Charles R. Thomas

doi:10.1016/0730-725X(94)92198-9

Utility of magnetization prepared GRE MRI for the detection of focal liver lesions

Thomas C. Winter, Patrick C. Freeny, Hanh V. Nghiem, Charles R. Thomas

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We compared the efficacy of rapidly acquired magnetization prepared gradient-echo (MP-GRE) sequences with CT and standard MRI pulse sequences for the detection of focal liver lesions. Fourteen patients with 28 focal liver lesions were scanned. TI times of 300, 450, and 600 ms were used. MP-GRE lesion conspicuity was compared to corresponding CT, T₁, T₂, T₂-postsuperparamagnetic-iron-oxide (SPIO), and STIR images. It was found that the differences between MP-GRE and CT and MP-GRE and T₁ MRI were not significant. However, overall anatomic detail was better with CT and T₁ MRI than MP-GRE. Lesion conspicuity was significantly worse with the MP-GRE than with the T₂, T₂-post-SPIO, and STIR sequences (all p values = 0.00). Maximal liver signal nulling occurred at TI = 300 ms in 13 out of 14 patients. However, the TI for optimal focal liver lesion conspicuity varied widely and could not be predicted before scanning. No new lesions were seen on the MP-GRE sequence that could not be seen on the CT or standard MRI sequences. As currently implemented, MP-GRE imaging offers no advantage in the detection of focal liver lesions over CT and standard MRI pulse sequences.

Original language	English (US)
Pages (from-to)	733-742
Number of pages	10
Journal	Magnetic Resonance Imaging
Volume	12
Issue number	5
DOIs	https://doi.org/10.1016/0730-725X(94)92198-9
State	Published - 1994
Externally published	Yes

Keywords

Diagnosis, magnetic resonance (MR)
Liver neoplasms
Pulse sequences

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Radiology Nuclear Medicine and imaging

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10.1016/0730-725X(94)92198-9

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title = "Utility of magnetization prepared GRE MRI for the detection of focal liver lesions",

abstract = "We compared the efficacy of rapidly acquired magnetization prepared gradient-echo (MP-GRE) sequences with CT and standard MRI pulse sequences for the detection of focal liver lesions. Fourteen patients with 28 focal liver lesions were scanned. TI times of 300, 450, and 600 ms were used. MP-GRE lesion conspicuity was compared to corresponding CT, T1, T2, T2-postsuperparamagnetic-iron-oxide (SPIO), and STIR images. It was found that the differences between MP-GRE and CT and MP-GRE and T1 MRI were not significant. However, overall anatomic detail was better with CT and T1 MRI than MP-GRE. Lesion conspicuity was significantly worse with the MP-GRE than with the T2, T2-post-SPIO, and STIR sequences (all p values = 0.00). Maximal liver signal nulling occurred at TI = 300 ms in 13 out of 14 patients. However, the TI for optimal focal liver lesion conspicuity varied widely and could not be predicted before scanning. No new lesions were seen on the MP-GRE sequence that could not be seen on the CT or standard MRI sequences. As currently implemented, MP-GRE imaging offers no advantage in the detection of focal liver lesions over CT and standard MRI pulse sequences.",

keywords = "Diagnosis, magnetic resonance (MR), Liver neoplasms, Pulse sequences",

author = "Winter, {Thomas C.} and Freeny, {Patrick C.} and Nghiem, {Hanh V.} and Thomas, {Charles R.}",

year = "1994",

doi = "10.1016/0730-725X(94)92198-9",

language = "English (US)",

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T1 - Utility of magnetization prepared GRE MRI for the detection of focal liver lesions

AU - Winter, Thomas C.

AU - Freeny, Patrick C.

AU - Nghiem, Hanh V.

AU - Thomas, Charles R.

PY - 1994

Y1 - 1994

N2 - We compared the efficacy of rapidly acquired magnetization prepared gradient-echo (MP-GRE) sequences with CT and standard MRI pulse sequences for the detection of focal liver lesions. Fourteen patients with 28 focal liver lesions were scanned. TI times of 300, 450, and 600 ms were used. MP-GRE lesion conspicuity was compared to corresponding CT, T1, T2, T2-postsuperparamagnetic-iron-oxide (SPIO), and STIR images. It was found that the differences between MP-GRE and CT and MP-GRE and T1 MRI were not significant. However, overall anatomic detail was better with CT and T1 MRI than MP-GRE. Lesion conspicuity was significantly worse with the MP-GRE than with the T2, T2-post-SPIO, and STIR sequences (all p values = 0.00). Maximal liver signal nulling occurred at TI = 300 ms in 13 out of 14 patients. However, the TI for optimal focal liver lesion conspicuity varied widely and could not be predicted before scanning. No new lesions were seen on the MP-GRE sequence that could not be seen on the CT or standard MRI sequences. As currently implemented, MP-GRE imaging offers no advantage in the detection of focal liver lesions over CT and standard MRI pulse sequences.

AB - We compared the efficacy of rapidly acquired magnetization prepared gradient-echo (MP-GRE) sequences with CT and standard MRI pulse sequences for the detection of focal liver lesions. Fourteen patients with 28 focal liver lesions were scanned. TI times of 300, 450, and 600 ms were used. MP-GRE lesion conspicuity was compared to corresponding CT, T1, T2, T2-postsuperparamagnetic-iron-oxide (SPIO), and STIR images. It was found that the differences between MP-GRE and CT and MP-GRE and T1 MRI were not significant. However, overall anatomic detail was better with CT and T1 MRI than MP-GRE. Lesion conspicuity was significantly worse with the MP-GRE than with the T2, T2-post-SPIO, and STIR sequences (all p values = 0.00). Maximal liver signal nulling occurred at TI = 300 ms in 13 out of 14 patients. However, the TI for optimal focal liver lesion conspicuity varied widely and could not be predicted before scanning. No new lesions were seen on the MP-GRE sequence that could not be seen on the CT or standard MRI sequences. As currently implemented, MP-GRE imaging offers no advantage in the detection of focal liver lesions over CT and standard MRI pulse sequences.

KW - Diagnosis, magnetic resonance (MR)

KW - Liver neoplasms

KW - Pulse sequences

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Utility of magnetization prepared GRE MRI for the detection of focal liver lesions

Abstract

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