Utility of magnetization prepared GRE MRI for the detection of focal liver lesions

Thomas C. Winter, Patrick C. Freeny, Hanh V. Nghiem, Charles R. Thomas

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


We compared the efficacy of rapidly acquired magnetization prepared gradient-echo (MP-GRE) sequences with CT and standard MRI pulse sequences for the detection of focal liver lesions. Fourteen patients with 28 focal liver lesions were scanned. TI times of 300, 450, and 600 ms were used. MP-GRE lesion conspicuity was compared to corresponding CT, T1, T2, T2-postsuperparamagnetic-iron-oxide (SPIO), and STIR images. It was found that the differences between MP-GRE and CT and MP-GRE and T1 MRI were not significant. However, overall anatomic detail was better with CT and T1 MRI than MP-GRE. Lesion conspicuity was significantly worse with the MP-GRE than with the T2, T2-post-SPIO, and STIR sequences (all p values = 0.00). Maximal liver signal nulling occurred at TI = 300 ms in 13 out of 14 patients. However, the TI for optimal focal liver lesion conspicuity varied widely and could not be predicted before scanning. No new lesions were seen on the MP-GRE sequence that could not be seen on the CT or standard MRI sequences. As currently implemented, MP-GRE imaging offers no advantage in the detection of focal liver lesions over CT and standard MRI pulse sequences.

Original languageEnglish (US)
Pages (from-to)733-742
Number of pages10
JournalMagnetic Resonance Imaging
Issue number5
StatePublished - 1994
Externally publishedYes


  • Diagnosis, magnetic resonance (MR)
  • Liver neoplasms
  • Pulse sequences

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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