Vaccine-mediated protection against campylobacter-associated enteric disease

Benjamin K. Quintel, Kamm Prongay, Anne D. Lewis, Hans Peter Raué, Sara Hendrickson, Nicholas S. Rhoades, Ilhem Messaoudi, Lina Gao, Mark K. Slifka, Ian J. Amanna

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Campylobacter coli and Campylobacter jejuni are responsible for 400 million to 500 million cases of enteric disease each year and represent the most common cause of bacterial gastroenteritis worldwide. Despite its global importance, Campylobacter vaccine development has been hampered by the lack of animal models that recapitulate human disease pathogenesis. Here, we describe a naturally occurring Campylobacter-associated diarrhea model in outdoor-housed rhesus macaques. Using this model, we developed novel next-generation H2O2-based Campylobacter vaccines that induced strong antibacterial antibodies to multiple Campylobacter proteins including flagellin and provided up to 83% protection against severe C. coli–associated diarrhea. Whole-genome sequencing of circulating Campylobacter strains revealed little to no homology within lipooligosaccharide or capsular polysaccharide loci with the Campylobacter vaccine strains used in these studies, indicating that vaccine-mediated immunity was not restricted to a single homologous serotype. Together, these results demonstrate an important advance in vaccine development and a new approach to reducing Campylobacter-associated enteric disease.

Original languageEnglish (US)
Article numbereaba4511
JournalScience Advances
Issue number26
StatePublished - Jun 2020

ASJC Scopus subject areas

  • General


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