Variable expression of soluble fms-like tyrosine kinase 1 in patients at high risk for preeclampsia

Bonnie K. Dwyer; Sacha Krieg; Raymond Balise; Ian R. Carroll; Jane Chueh; Nihar Nayak; Maurice Druzin

doi:10.3109/14767050903258753

Variable expression of soluble fms-like tyrosine kinase 1 in patients at high risk for preeclampsia

Bonnie K. Dwyer
, Sacha Krieg
, Raymond Balise
, Ian R. Carroll
, Jane Chueh
, Nihar Nayak
, Maurice Druzin

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Objective.To explore angiogenic factor differences in preeclamptic patients according to the absence or presence of underlying vascular disease. Methods.We prospectively compared serum soluble fms-like tyrosine kinase 1 (sFlt1), soluble endoglin, and placental growth factor (PlGF) from 41 normal-risk and 32 high-risk (preexisting conditions) subjects at serial gestational ages. Results.Median sFlt1 was lower at delivery in preeclamptic patients with underlying chronic hypertension and/or chronic proteinuria (5115pg/ml) compared with normal risk preeclamptic patients (16375pg/ml). PlGF was consistently low in patients who developed preeclampsia. Conclusions.Effects of sFlt1 may be contextual, varying according to the health or disease state of vascular endothelium.

Original language	English (US)
Pages (from-to)	705-711
Number of pages	7
Journal	Journal of Maternal-Fetal and Neonatal Medicine
Volume	23
Issue number	7
DOIs	https://doi.org/10.3109/14767050903258753
State	Published - Jul 2010
Externally published	Yes

Funding

This study was supported by ACOG-Ortho McNeil Research Fellowship 2005–2006 and the Division of Maternal Fetal Medicine, Stanford University.

Funders	Funder number
ACOG-Ortho McNeil
Maternal-Fetal Medicine Division
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health	K23DA025152
Department of Biological Sciences Stanford University Stanford

Keywords

High risk pregnancy
Hypertension
Placental growth factor
Preeclampsia
Proteinuria
Soluble endoglin
Soluble fms-like tyrosine kinase 1

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

Access to Document

10.3109/14767050903258753

Cite this

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title = "Variable expression of soluble fms-like tyrosine kinase 1 in patients at high risk for preeclampsia",

abstract = "Objective.To explore angiogenic factor differences in preeclamptic patients according to the absence or presence of underlying vascular disease. Methods.We prospectively compared serum soluble fms-like tyrosine kinase 1 (sFlt1), soluble endoglin, and placental growth factor (PlGF) from 41 normal-risk and 32 high-risk (preexisting conditions) subjects at serial gestational ages. Results.Median sFlt1 was lower at delivery in preeclamptic patients with underlying chronic hypertension and/or chronic proteinuria (5115pg/ml) compared with normal risk preeclamptic patients (16375pg/ml). PlGF was consistently low in patients who developed preeclampsia. Conclusions.Effects of sFlt1 may be contextual, varying according to the health or disease state of vascular endothelium.",

keywords = "High risk pregnancy, Hypertension, Placental growth factor, Preeclampsia, Proteinuria, Soluble endoglin, Soluble fms-like tyrosine kinase 1",

author = "Dwyer, \{Bonnie K.\} and Sacha Krieg and Raymond Balise and Carroll, \{Ian R.\} and Jane Chueh and Nihar Nayak and Maurice Druzin",

note = "Funding Information: This study was supported by ACOG-Ortho McNeil Research Fellowship 2005–2006 and the Division of Maternal Fetal Medicine, Stanford University.",

year = "2010",

month = jul,

doi = "10.3109/14767050903258753",

language = "English (US)",

volume = "23",

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T1 - Variable expression of soluble fms-like tyrosine kinase 1 in patients at high risk for preeclampsia

AU - Dwyer, Bonnie K.

AU - Krieg, Sacha

AU - Balise, Raymond

AU - Carroll, Ian R.

AU - Chueh, Jane

AU - Nayak, Nihar

AU - Druzin, Maurice

N1 - Funding Information: This study was supported by ACOG-Ortho McNeil Research Fellowship 2005–2006 and the Division of Maternal Fetal Medicine, Stanford University.

PY - 2010/7

Y1 - 2010/7

N2 - Objective.To explore angiogenic factor differences in preeclamptic patients according to the absence or presence of underlying vascular disease. Methods.We prospectively compared serum soluble fms-like tyrosine kinase 1 (sFlt1), soluble endoglin, and placental growth factor (PlGF) from 41 normal-risk and 32 high-risk (preexisting conditions) subjects at serial gestational ages. Results.Median sFlt1 was lower at delivery in preeclamptic patients with underlying chronic hypertension and/or chronic proteinuria (5115pg/ml) compared with normal risk preeclamptic patients (16375pg/ml). PlGF was consistently low in patients who developed preeclampsia. Conclusions.Effects of sFlt1 may be contextual, varying according to the health or disease state of vascular endothelium.

AB - Objective.To explore angiogenic factor differences in preeclamptic patients according to the absence or presence of underlying vascular disease. Methods.We prospectively compared serum soluble fms-like tyrosine kinase 1 (sFlt1), soluble endoglin, and placental growth factor (PlGF) from 41 normal-risk and 32 high-risk (preexisting conditions) subjects at serial gestational ages. Results.Median sFlt1 was lower at delivery in preeclamptic patients with underlying chronic hypertension and/or chronic proteinuria (5115pg/ml) compared with normal risk preeclamptic patients (16375pg/ml). PlGF was consistently low in patients who developed preeclampsia. Conclusions.Effects of sFlt1 may be contextual, varying according to the health or disease state of vascular endothelium.

KW - High risk pregnancy

KW - Hypertension

KW - Placental growth factor

KW - Preeclampsia

KW - Proteinuria

KW - Soluble endoglin

KW - Soluble fms-like tyrosine kinase 1

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Variable expression of soluble fms-like tyrosine kinase 1 in patients at high risk for preeclampsia

Abstract

Funding

Keywords

ASJC Scopus subject areas

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