TY - JOUR
T1 - Variation of the Relaxographic "Shutter-Speed" for Transcytolemmal Water Exchange Affects the CR Bolus-Tracking Curve Shape
AU - Yankeelov, Thomas E.
AU - Rooney, William D.
AU - Li, Xin
AU - Springer, Charles S.
PY - 2003/12
Y1 - 2003/12
N2 - Contrast reagents (CRs) may enter the tissue interstitium for a period after a vascular bolus injection. As the amount of interstitial CR increases, the longitudinal relaxographic NMR "shutter-speed" (T-1) for the equilibrium transcytolemmal water exchange process increases. The quantity T-1 is given by [r1o[CRo] + R 1o0 - R1i| (where r1o and [CRo] represent the interstitial (extracellular) CR relaxivity and concentration, respectively, and R1o0 and R1i are the extra- and intracellular 1H2O relaxation rate constants, respectively, in the absence of exchange). The increase of T-1 with [CRo] causes the kinetics of the water exchange equilibrium to appear to decrease. Here, analytical theory for two-site-exchange processes is combined with that for pharmacokinetic CR delivery, extraction, and distribution in a method termed BOLus Enhanced Relaxation Overview (BOLERO
AB - Contrast reagents (CRs) may enter the tissue interstitium for a period after a vascular bolus injection. As the amount of interstitial CR increases, the longitudinal relaxographic NMR "shutter-speed" (T-1) for the equilibrium transcytolemmal water exchange process increases. The quantity T-1 is given by [r1o[CRo] + R 1o0 - R1i| (where r1o and [CRo] represent the interstitial (extracellular) CR relaxivity and concentration, respectively, and R1o0 and R1i are the extra- and intracellular 1H2O relaxation rate constants, respectively, in the absence of exchange). The increase of T-1 with [CRo] causes the kinetics of the water exchange equilibrium to appear to decrease. Here, analytical theory for two-site-exchange processes is combined with that for pharmacokinetic CR delivery, extraction, and distribution in a method termed BOLus Enhanced Relaxation Overview (BOLERO
KW - CR bolus-tracking
KW - Intracellular water lifetime
KW - Shutter-speed
UR - http://www.scopus.com/inward/record.url?scp=0344305582&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0344305582&partnerID=8YFLogxK
U2 - 10.1002/mrm.10624
DO - 10.1002/mrm.10624
M3 - Article
C2 - 14648563
AN - SCOPUS:0344305582
SN - 0740-3194
VL - 50
SP - 1151
EP - 1169
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 6
ER -