@article{3c66459aa73240e5a8815ae4e9e7b4ea,
title = "Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques",
abstract = "Aid et al. show that SARS-CoV-2 causes endothelial disruption and vascular thrombosis in both human and rhesus macaques lungs by inducing an upregulation of proinflammatory cytokines. Using an approach that combines histopathology and multiomics in macaques, they show the progression to vascular disease over time, which involves complement, macrophage, cytokine, and thrombosis cascades.",
keywords = "IFNα, SARS-CoV-2, coagulation, collagen, complement, macrophage, platelet, thrombosis, vWF, vascular",
author = "Malika Aid and Kathleen Busman-Sahay and Vidal, {Samuel J.} and Zoltan Maliga and Stephen Bondoc and Carly Starke and Margaret Terry and Jacobson, {Connor A.} and Linda Wrijil and Sarah Ducat and Brook, {Olga R.} and Miller, {Andrew D.} and Maciel Porto and Pellegrini, {Kathryn L.} and Maria Pino and Hoang, {Timothy N.} and Abishek Chandrashekar and Shivani Patel and Kathryn Stephenson and Bosinger, {Steven E.} and Hanne Andersen and Lewis, {Mark G.} and Hecht, {Jonathan L.} and Sorger, {Peter K.} and Martinot, {Amanda J.} and Estes, {Jacob D.} and Barouch, {Dan H.}",
note = "Funding Information: We thank L. Pessaint, M. Paiardini, G. Tharp, R. Flaumenhaft, N. Johnson, and the SomaLogic assay services team for generous advice, assistance, and reagents. We acknowledge support from the Ragon Institute of MGH, MIT and Harvard; Mark and Lisa Schwartz Foundation; Beth Israel Deaconess Medical Center; Massachusetts Consortium on Pathogen Readiness (MassCPR); Bill & Melinda Gates Foundation (INV-006131); and the National Institutes of Health (OD024917, CA260476, AI124377, AI126603, AI128751, AI129797, and AI149670). The Yerkes Genomics Core is supported in part by NIH P51 OD011132, and sequencing data were acquired on an Illumina NovaSeq6000 funded by NIH S10 OD026799. D.H.B. and M.A. designed the study. M.A. performed the transcriptomic and proteomics data analysis and interpretation. J.D.E. K.B.-S. Z.M. C.A.J. P.K.S. A.J.M. J.L.H. L.W. S.D. O.R.B. and A.D.M. performed the pathology studies. K.L.P, M. Pino, T.N.H. and S.E.B performed the bulk RNA-seq and generated the BAL and peripheral blood raw data. A.C. and S.P. helped with sample processing. M. Porto performed the Luminex assay. D.H.B. M.A. and S.J.V. wrote the paper with all co-authors. The authors declare no competing interests. Funding Information: We thank L. Pessaint, M. Paiardini, G. Tharp, R. Flaumenhaft, N. Johnson, and the SomaLogic assay services team for generous advice, assistance, and reagents. We acknowledge support from the Ragon Institute of MGH, MIT and Harvard ; Mark and Lisa Schwartz Foundation ; Beth Israel Deaconess Medical Center ; Massachusetts Consortium on Pathogen Readiness (MassCPR); Bill & Melinda Gates Foundation ( INV-006131 ); and the National Institutes of Health ( OD024917 , CA260476 , AI124377 , AI126603 , AI128751 , AI129797 , and AI149670 ). The Yerkes Genomics Core is supported in part by NIH P51 OD011132 , and sequencing data were acquired on an Illumina NovaSeq6000 funded by NIH S10 OD026799 . Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = nov,
day = "25",
doi = "10.1016/j.cell.2020.10.005",
language = "English (US)",
volume = "183",
pages = "1354--1366.e13",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "5",
}