Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

Malika Aid; Kathleen Busman-Sahay; Samuel J. Vidal; Zoltan Maliga; Stephen Bondoc; Carly Starke; Margaret Terry; Connor A. Jacobson; Linda Wrijil; Sarah Ducat; Olga R. Brook; Andrew D. Miller; Maciel Porto; Kathryn L. Pellegrini; Maria Pino; Timothy N. Hoang; Abishek Chandrashekar; Shivani Patel; Kathryn Stephenson; Steven E. Bosinger; Hanne Andersen; Mark G. Lewis; Jonathan L. Hecht; Peter K. Sorger; Amanda J. Martinot; Jacob D. Estes; Dan H. Barouch

doi:10.1016/j.cell.2020.10.005

Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

Malika Aid, Kathleen Busman-Sahay, Samuel J. Vidal, Zoltan Maliga, Stephen Bondoc, Carly Starke, Margaret Terry, Connor A. Jacobson, Linda Wrijil, Sarah Ducat, Olga R. Brook, Andrew D. Miller, Maciel Porto, Kathryn L. Pellegrini, Maria Pino, Timothy N. Hoang, Abishek Chandrashekar, Shivani Patel, Kathryn Stephenson, Steven E. BosingerHanne Andersen, Mark G. Lewis, Jonathan L. Hecht, Peter K. Sorger, Amanda J. Martinot, Jacob D. Estes, Dan H. Barouch

Vaccine and Gene Therapy Institute

Research output: Contribution to journal › Article › peer-review

148 Scopus citations

Abstract

Aid et al. show that SARS-CoV-2 causes endothelial disruption and vascular thrombosis in both human and rhesus macaques lungs by inducing an upregulation of proinflammatory cytokines. Using an approach that combines histopathology and multiomics in macaques, they show the progression to vascular disease over time, which involves complement, macrophage, cytokine, and thrombosis cascades.

Original language	English (US)
Pages (from-to)	1354-1366.e13
Journal	Cell
Volume	183
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2020.10.005
State	Published - Nov 25 2020

Keywords

IFNα
SARS-CoV-2
coagulation
collagen
complement
macrophage
platelet
thrombosis
vWF
vascular

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.cell.2020.10.005

Cite this

Aid, M., Busman-Sahay, K., Vidal, S. J., Maliga, Z., Bondoc, S., Starke, C., Terry, M., Jacobson, C. A., Wrijil, L., Ducat, S., Brook, O. R., Miller, A. D., Porto, M., Pellegrini, K. L., Pino, M., Hoang, T. N., Chandrashekar, A., Patel, S., Stephenson, K., ... Barouch, D. H. (2020). Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques. Cell, 183(5), 1354-1366.e13. https://doi.org/10.1016/j.cell.2020.10.005

Aid, M, Busman-Sahay, K, Vidal, SJ, Maliga, Z, Bondoc, S, Starke, C, Terry, M, Jacobson, CA, Wrijil, L, Ducat, S, Brook, OR, Miller, AD, Porto, M, Pellegrini, KL, Pino, M, Hoang, TN, Chandrashekar, A, Patel, S, Stephenson, K, Bosinger, SE, Andersen, H, Lewis, MG, Hecht, JL, Sorger, PK, Martinot, AJ, Estes, JD & Barouch, DH 2020, 'Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques', Cell, vol. 183, no. 5, pp. 1354-1366.e13. https://doi.org/10.1016/j.cell.2020.10.005

@article{3c66459aa73240e5a8815ae4e9e7b4ea,

title = "Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques",

abstract = "Aid et al. show that SARS-CoV-2 causes endothelial disruption and vascular thrombosis in both human and rhesus macaques lungs by inducing an upregulation of proinflammatory cytokines. Using an approach that combines histopathology and multiomics in macaques, they show the progression to vascular disease over time, which involves complement, macrophage, cytokine, and thrombosis cascades.",

keywords = "IFNα, SARS-CoV-2, coagulation, collagen, complement, macrophage, platelet, thrombosis, vWF, vascular",

author = "Malika Aid and Kathleen Busman-Sahay and Vidal, {Samuel J.} and Zoltan Maliga and Stephen Bondoc and Carly Starke and Margaret Terry and Jacobson, {Connor A.} and Linda Wrijil and Sarah Ducat and Brook, {Olga R.} and Miller, {Andrew D.} and Maciel Porto and Pellegrini, {Kathryn L.} and Maria Pino and Hoang, {Timothy N.} and Abishek Chandrashekar and Shivani Patel and Kathryn Stephenson and Bosinger, {Steven E.} and Hanne Andersen and Lewis, {Mark G.} and Hecht, {Jonathan L.} and Sorger, {Peter K.} and Martinot, {Amanda J.} and Estes, {Jacob D.} and Barouch, {Dan H.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = nov,

day = "25",

doi = "10.1016/j.cell.2020.10.005",

language = "English (US)",

volume = "183",

pages = "1354--1366.e13",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "5",

}

TY - JOUR

T1 - Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

AU - Aid, Malika

AU - Busman-Sahay, Kathleen

AU - Vidal, Samuel J.

AU - Maliga, Zoltan

AU - Bondoc, Stephen

AU - Starke, Carly

AU - Terry, Margaret

AU - Jacobson, Connor A.

AU - Wrijil, Linda

AU - Ducat, Sarah

AU - Brook, Olga R.

AU - Miller, Andrew D.

AU - Porto, Maciel

AU - Pellegrini, Kathryn L.

AU - Pino, Maria

AU - Hoang, Timothy N.

AU - Chandrashekar, Abishek

AU - Patel, Shivani

AU - Stephenson, Kathryn

AU - Bosinger, Steven E.

AU - Andersen, Hanne

AU - Lewis, Mark G.

AU - Hecht, Jonathan L.

AU - Sorger, Peter K.

AU - Martinot, Amanda J.

AU - Estes, Jacob D.

AU - Barouch, Dan H.

PY - 2020/11/25

Y1 - 2020/11/25

N2 - Aid et al. show that SARS-CoV-2 causes endothelial disruption and vascular thrombosis in both human and rhesus macaques lungs by inducing an upregulation of proinflammatory cytokines. Using an approach that combines histopathology and multiomics in macaques, they show the progression to vascular disease over time, which involves complement, macrophage, cytokine, and thrombosis cascades.

AB - Aid et al. show that SARS-CoV-2 causes endothelial disruption and vascular thrombosis in both human and rhesus macaques lungs by inducing an upregulation of proinflammatory cytokines. Using an approach that combines histopathology and multiomics in macaques, they show the progression to vascular disease over time, which involves complement, macrophage, cytokine, and thrombosis cascades.

KW - IFNα

KW - SARS-CoV-2

KW - coagulation

KW - collagen

KW - complement

KW - macrophage

KW - platelet

KW - thrombosis

KW - vWF

KW - vascular

UR - http://www.scopus.com/inward/record.url?scp=85092613402&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85092613402&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2020.10.005

DO - 10.1016/j.cell.2020.10.005

M3 - Article

C2 - 33065030

AN - SCOPUS:85092613402

SN - 0092-8674

VL - 183

SP - 1354-1366.e13

JO - Cell

JF - Cell

IS - 5

ER -

Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this