Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

Malika Aid, Kathleen Busman-Sahay, Samuel J. Vidal, Zoltan Maliga, Stephen Bondoc, Carly Starke, Margaret Terry, Connor A. Jacobson, Linda Wrijil, Sarah Ducat, Olga R. Brook, Andrew D. Miller, Maciel Porto, Kathryn L. Pellegrini, Maria Pino, Timothy N. Hoang, Abishek Chandrashekar, Shivani Patel, Kathryn Stephenson, Steven E. BosingerHanne Andersen, Mark G. Lewis, Jonathan L. Hecht, Peter K. Sorger, Amanda J. Martinot, Jacob D. Estes, Dan H. Barouch

Research output: Contribution to journalArticlepeer-review

133 Scopus citations


Aid et al. show that SARS-CoV-2 causes endothelial disruption and vascular thrombosis in both human and rhesus macaques lungs by inducing an upregulation of proinflammatory cytokines. Using an approach that combines histopathology and multiomics in macaques, they show the progression to vascular disease over time, which involves complement, macrophage, cytokine, and thrombosis cascades.

Original languageEnglish (US)
Pages (from-to)1354-1366.e13
Issue number5
StatePublished - Nov 25 2020


  • IFNα
  • SARS-CoV-2
  • coagulation
  • collagen
  • complement
  • macrophage
  • platelet
  • thrombosis
  • vWF
  • vascular

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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