Vincristine in the etiology of toxicity of high‐dose methotrexate therapy

Derry Ridgway; Diane C. Renholds; Robert C. Neerhout; Lawrence J. Wolff

doi:10.1002/1097-0142(19801215)46:12<2571::AID-CNCR2820461206>3.0.CO;2-W

Vincristine in the etiology of toxicity of high‐dose methotrexate therapy

Derry Ridgway, Diane C. Renholds, Robert C. Neerhout, Lawrence J. Wolff

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A 14‐year‐old boy received a six‐hour infusion of methotrexate (7 ½ g/M²) with vincristine (2 mg) and citrovorum rescue according to a standard protocol for adjunctive chemotherapy of osteogenic sarcoma. Signs of mild vincristine toxicity occurred from 2–5 days following the infusion; these included jaw pain, decreases in deep tendon reflexes, and a transient ileus. Clearance of serum methotrexate was delayed during the period of ileus and severe methotrexate toxicity was observed.

Original language	English (US)
Pages (from-to)	2571-2572
Number of pages	2
Journal	Cancer
Volume	46
Issue number	12
DOIs	https://doi.org/10.1002/1097-0142(19801215)46:12<2571::AID-CNCR2820461206>3.0.CO;2-W
State	Published - Dec 15 1980
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19801215)46:12<2571::AID-CNCR2820461206>3.0.CO;2-W

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title = "Vincristine in the etiology of toxicity of high‐dose methotrexate therapy",

abstract = "A 14‐year‐old boy received a six‐hour infusion of methotrexate (7 ½ g/M2) with vincristine (2 mg) and citrovorum rescue according to a standard protocol for adjunctive chemotherapy of osteogenic sarcoma. Signs of mild vincristine toxicity occurred from 2–5 days following the infusion; these included jaw pain, decreases in deep tendon reflexes, and a transient ileus. Clearance of serum methotrexate was delayed during the period of ileus and severe methotrexate toxicity was observed.",

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T1 - Vincristine in the etiology of toxicity of high‐dose methotrexate therapy

AU - Ridgway, Derry

AU - Renholds, Diane C.

AU - Neerhout, Robert C.

AU - Wolff, Lawrence J.

PY - 1980/12/15

Y1 - 1980/12/15

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AB - A 14‐year‐old boy received a six‐hour infusion of methotrexate (7 ½ g/M2) with vincristine (2 mg) and citrovorum rescue according to a standard protocol for adjunctive chemotherapy of osteogenic sarcoma. Signs of mild vincristine toxicity occurred from 2–5 days following the infusion; these included jaw pain, decreases in deep tendon reflexes, and a transient ileus. Clearance of serum methotrexate was delayed during the period of ileus and severe methotrexate toxicity was observed.

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ER -

Vincristine in the etiology of toxicity of high‐dose methotrexate therapy

Abstract

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