TY - JOUR
T1 - Viral inhibition of MHC class II antigen presentation
AU - Hegde, Nagendra R.
AU - Chevalier, Mathieu S.
AU - Johnson, David C.
N1 - Funding Information:
We thank Curt Horvath, Philippe Benaroch, Joanne Trgovcich, Daniel Sedmak and John Trowsdale for critical input to this manuscript. We are grateful to Tiffani Howard for the artwork. We apologize to those whose original work could not be cited due to space limitations. Our own work was supported by NIH grants EY11245 and CA73996.
PY - 2003/5/1
Y1 - 2003/5/1
N2 - CD4+ T cells can recognize antigens expressed in virus-infected cells and act cytolytically, to produce antiviral cytokines or to co-ordinate antiviral immune responses. Viruses escape detection by CD4+ T cells by at least two mechanisms. First, and perhaps foremost, viruses inhibit induction of the expression of MHC class II genes by blocking interferon-γ (IFN-γ) signal transduction and expression of the MHC class II transactivator (CIITA). Second, viruses inhibit the MHC class II antigen presentation pathway by affecting the stability or intracellular sorting of class II proteins. It appears that this viral inhibition is designed to prevent presentation of endogenous viral antigens in virus-infected host cells, rather than presentation of exogenous antigens in 'professional' antigen-presenting cells.
AB - CD4+ T cells can recognize antigens expressed in virus-infected cells and act cytolytically, to produce antiviral cytokines or to co-ordinate antiviral immune responses. Viruses escape detection by CD4+ T cells by at least two mechanisms. First, and perhaps foremost, viruses inhibit induction of the expression of MHC class II genes by blocking interferon-γ (IFN-γ) signal transduction and expression of the MHC class II transactivator (CIITA). Second, viruses inhibit the MHC class II antigen presentation pathway by affecting the stability or intracellular sorting of class II proteins. It appears that this viral inhibition is designed to prevent presentation of endogenous viral antigens in virus-infected host cells, rather than presentation of exogenous antigens in 'professional' antigen-presenting cells.
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U2 - 10.1016/S1471-4906(03)00099-1
DO - 10.1016/S1471-4906(03)00099-1
M3 - Review article
C2 - 12738423
AN - SCOPUS:0038401122
SN - 1471-4906
VL - 24
SP - 278
EP - 285
JO - Trends in Immunology
JF - Trends in Immunology
IS - 5
ER -